ArticleJournal of radiation research2018
Dose-response curves for analyzing of dicentric chromosomes and chromosome translocations following doses of 1000 mGy or less, based on irradiated peripheral blood samples from five healthy individuals.
Article in Journal of radiation research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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15 citing papers in PubMed, 34 citations in OpenAlex.
- Occupational radiation exposure indicated by increased chromosomal damage in lymphocytes of orthopaedic surgeons in Japan.Journal of radiation research · 2026Article
- Optimized dicentric chromosome dose-response curves with centromere probes improve low-dose radiation biodosimetry.Scientific reports · 2026Article
- Impact of Low-Dose CT Radiation on Gene Expression and DNA Integrity.International journal of molecular sciences · 2025Article
- Synergistic Genotoxic Effects of Gamma Rays and UVB Radiation on Human Blood.Antioxidants (Basel, Switzerland) · 2025Article
- No increase in translocated chromosomal aberrations, an indicator of ionizing radiation exposure, in childhood thyroid cancer in Fukushima Prefecture.Scientific reports · 2023Article
- Dicentric chromosome assay using a deep learning-based automated system.Scientific reports · 2022Article
- Haptoglobin is an early indicator of survival after radiation-induced severe injury and bone marrow transplantation in mice.Stem cell research & therapy · 2022Article
- Hypersensitivity and Induced Radioresistance in Chinese Hamster Cells Exposed to Radiations with Different LET Values.International journal of molecular sciences · 2022Article
- Early Biomarkers Associated with P53 Signaling for Acute Radiation Injury.Life (Basel, Switzerland) · 2022Article
- Radiobiological risks following dentomaxillofacial imaging: should we be concerned?Dento maxillo facial radiology · 2021Review
- Correspondence: Response to "Evaluating the Cumulative Impact of Ionizing Radiation Exposure With Diagnostic Genetics".Annals of laboratory medicine · 2019Article
- Dose Estimation Curves Following In Vitro X-ray Irradiation Using Blood From Four Healthy Korean Individuals.Annals of laboratory medicine · 2019Article
- Biological dosimetry dose-response curves for residents living near nuclear power plants in South Korea.Science progressArticle
- BPIFA2 as a Novel Early Biomarker to Identify Fatal Radiation Injury After Radiation Exposure.Dose-response : a publication of International Hormesis SocietyArticle
- High-Throughput Automated Construction and Validation of Dicentric Chromosome and Micronucleus Biodosimetry Calibration Curves for Radiation Emergency Response.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In terms of biological dosimetry at the time of radiation exposure, the dicentric chromosome (Dic) assay (DCA) is the gold standard for assessing for the acute phase and chromosome translocation (Tr) analysis is the gold standard for assessing the chronic phase. It is desirable to have individual dose-response curves (DRCs) for each laboratory because the analysis criteria differ between laboratories. We constructed the DRCs for radiation dose estimation (with three methods) using peripheral blood (PB) samples from five healthy individuals. Aliquots were irradiated with one of eight gamma-ray doses (0, 10, 20, 50, 100, 200, 500 or 1000 mGy), then cultured for 48 h. The number of chromosome aberrations (CAs) was analyzed by DCA, using Giemsa staining and centromere-fluorescence in situ hybridization (centromere-FISH) and by chromosome painting (chromosome pairs 1, 2 and 4) for Tr analysis. In DCA, there was large variation between individuals in the frequency of Dics formed, and the slopes of the DRCs were different. In Tr analysis, although variation was observed in the frequency of Tr, the slopes of the DRCs were similar after adjusting the background for age. Good correlation between the irradiation dose and the frequency of CAs formed was observed with these three DRCs. However, performing three different biological dosimetry assays simultaneously on PB from five donors nonetheless results in variation in the frequency of CAs formed, especially at doses of 50 mGy or less, highlighting the difficulty of biological dosimetry using these methods. We conclude that it might be difficult to construct universal DRCs.
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