Evidence map›Paper›PMID 29040640›Full record

ArticleJournal of neuropathology and experimental neurology2017

Pathology-MRI Correlations in Diffuse Low-Grade Epilepsy Associated Tumors.

Aliya Al-Hajri, Salim Al-Mughairi, Alyma Somani, Shu An, Joan Liu, Anna Miserocchi, Andrew W McEvoy, Tarek Yousry, Chandrashekar Hoskote, Maria Thom

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuropathology and experimental neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Neuroimaging features of angiocentric glioma: A case series and systematic review.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022
    Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aliya Al-HajriLysholm Department of Neuroradiology in National Hospital for Neurology and Neurosurgery, London, UK; Division of Neuropathology, National Hospital for Neurology and Neurosurgery, London, UK; Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK; and Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.
Salim Al-MughairiLysholm Department of Neuroradiology in National Hospital for Neurology and Neurosurgery, London, UK; Division of Neuropathology, National Hospital for Neurology and Neurosurgery, London, UK; Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK; and Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.
Alyma SomaniLysholm Department of Neuroradiology in National Hospital for Neurology and Neurosurgery, London, UK; Division of Neuropathology, National Hospital for Neurology and Neurosurgery, London, UK; Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK; and Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.
Shu AnLysholm Department of Neuroradiology in National Hospital for Neurology and Neurosurgery, London, UK; Division of Neuropathology, National Hospital for Neurology and Neurosurgery, London, UK; Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK; and Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.
Joan LiuLysholm Department of Neuroradiology in National Hospital for Neurology and Neurosurgery, London, UK; Division of Neuropathology, National Hospital for Neurology and Neurosurgery, London, UK; Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK; and Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.
Anna MiserocchiLysholm Department of Neuroradiology in National Hospital for Neurology and Neurosurgery, London, UK; Division of Neuropathology, National Hospital for Neurology and Neurosurgery, London, UK; Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK; and Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.
Andrew W McEvoyLysholm Department of Neuroradiology in National Hospital for Neurology and Neurosurgery, London, UK; Division of Neuropathology, National Hospital for Neurology and Neurosurgery, London, UK; Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK; and Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.
Tarek YousryLysholm Department of Neuroradiology in National Hospital for Neurology and Neurosurgery, London, UK; Division of Neuropathology, National Hospital for Neurology and Neurosurgery, London, UK; Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK; and Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.
Chandrashekar HoskoteLysholm Department of Neuroradiology in National Hospital for Neurology and Neurosurgery, London, UK; Division of Neuropathology, National Hospital for Neurology and Neurosurgery, London, UK; Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK; and Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.
Maria ThomLysholm Department of Neuroradiology in National Hospital for Neurology and Neurosurgery, London, UK; Division of Neuropathology, National Hospital for Neurology and Neurosurgery, London, UK; Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK; and Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, London, UK.

Funding

Medical Research Council MR/J01270X/1
6 · The paper itself

Abstract

It is recognized that IDH mutation negative, low-grade epilepsy associated tumors (LEAT) can show diffuse growth patterns and lack the diagnostic hallmarks of either classical dysembryoplastic neuroepithelial tumors (DNT) or typical ganglioglioma. "Nonspecific or diffuse DNT" and more recently "polymorphous low-grade neuroepithelial tumor of the young" have been terms used for these entities. There are few reports on the MRI recognition of these diffuse glioneuronal tumors (dGNT), which is important in planning the extent of surgical resection. In 27 LEATs T1, T2, FLAIR, and postcontrast T1 MRI were evaluated and the pathology reviewed, including immunostaining for NeuN, CD34, MAP2, and IDH1. Each case was then independently classified by pathology or MRI as simple DNT, complex DNT, or dGNT. There was agreement in 23/27 (85%; Kappa score 0.62; p < 0.01). In 4 cases, there was discrepancy in the diagnosis of simple versus complex DNT but 100% agreement achieved for dGNT. DNT showed significantly more expansion of the cortex, cystic change and ventricle extension than dGNT. dGNT showed significantly more subcortical T2w hyperintensity and focal cortical atrophy which correlated on pathology with CD34 expression, cortical neuronal loss and white matter rarefaction. There was no distinct cortical dysplasia component identified by MRI or pathology in any case. This study highlights that dGNT can be reliably discriminated on MRI from DNT.

Indexed as

Magnetic Resonance ImagingAdolescentAdultBrain NeoplasmsEpilepsyFemaleHumansMaleMiddle AgedNeoplasm GradingRetrospective StudiesYoung AdultDysembryoplastic neuroepithelial tumors (DNT)Long-term epilepsy associated tumorsMRI

Identifiers

PMID29040640
PMCPMC5939705

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