Evidence map›Paper›PMID 29040621›Full record

ReviewThe Journal of infectious diseases2017

Current Status of Point-of-Care Testing for Human Immunodeficiency Virus Drug Resistance.

Horacio A Duarte, Nuttada Panpradist, Ingrid A Beck, Barry Lutz, James Lai, Ruth M Kanthula, Rami Kantor, Anubhav Tripathi, Shanmugam Saravanan, Iain J MacLeod and 4 more

Abstract readReview
In one paragraph

Review in The Journal of infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Lassa Virus Genetics.Current topics in microbiology and immunology · 2023
    Article
  6. Article
  7. The Path Forward for COVID-19 Diagnostics.Molecular diagnosis & therapy · 2020
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Nucleic acid testing and molecular characterization of HIV infections.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019
    Review
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Horacio A DuarteDepartment of Pediatrics, Division of Infectious Diseases.
Nuttada PanpradistDepartment of Bioengineering, University of Washington.
Ingrid A BeckSeattle Children's Research Instituten.
Barry LutzDepartment of Bioengineering, University of Washington.
James LaiDepartment of Bioengineering, University of Washington.
Ruth M KanthulaDepartment of Pediatrics, Division of Infectious Diseases.
Rami KantorDepartment of Medicine, Division of Infectious Diseases.
Anubhav TripathiCenter for Biomedical Engineering, School of Engineering.
Shanmugam SaravananYRG CARE, India.
Iain J MacLeodAldatu Biosciences, Harvard Life Lab.
Michael H ChungDepartment of Global Health.
Guoqing ZhangCenter for Global Health, Division of Global HIV and Tuberculosis, Centers for Disease Control and Prevention.
Chunfu YangCenter for Global Health, Division of Global HIV and Tuberculosis, Centers for Disease Control and Prevention.
Lisa M FrenkelDepartment of Pediatrics, Division of Infectious Diseases.

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7M
LC - IMPAACT Leadership GroupUM1AI106716 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$47.2M
Pediatric Scientist Development Program (PSDP) [K12]K12HD000850 · NICHD · YALE UNIVERSITY · PI Sallie R. Permar · 1987 to 2026
$44.1M
Drug-resistance testing in Kenya to improve ART suppression of HIV replicationR01AI100037 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI FRENKEL, LISA M · 2012 to 2014
$3.1M
PANDAA for rapid genotyping of HIV-1 infected patients failing protease inhibitor ART in resource-limited settingsR44AI128974 · NIAID · ALDATU BIOSCIENCES, INC. · PI MACLEOD, IAIN JAMES · 2017 to 2019
$2.9M
A rapid point-of-treatment diagnostic assay for HIV-resistance to 1st-line ARTR01AI110375 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI FRENKEL, LISA M · 2014 to 2018
$2.3M
A Rapid, Cost-Effective HIV Drug Resistance Diagnostic for Resource-Limited SettingsR44AI118441 · NIAID · ALDATU BIOSCIENCES, INC. · PI MACLEOD, IAIN JAMES · 2015 to 2016
$1.5M
HIV Drug Resistance Monitoring in Chennai, IndiaR21AI106392 · NIAID · MIRIAM HOSPITAL · PI KANTOR, RAMI, KATZENSTEIN, DAVID ALLENBERG · 2013 to 2014
$417k
NIAID NIH HHS P30 AI042853NIAID NIH HHS R01 AI100037NIAID NIH HHS R01 AI110375NIAID NIH HHS R21 AI106392NIAID NIH HHS R44 AI118441NIAID NIH HHS R44 AI128974NIAID NIH HHS UM1 AI106716NICHD NIH HHS K12 HD000850
6 · The paper itself

Abstract

Healthcare delivery has advanced due to the implementation of point-of-care testing, which is often performed within minutes to hours in minimally equipped laboratories or at home. Technologic advances are leading to point-of-care kits that incorporate nucleic acid-based assays, including polymerase chain reaction, isothermal amplification, ligation, and hybridization reactions. As a limited number of single-nucleotide polymorphisms are associated with clinically significant human immunodeficiency virus (HIV) drug resistance, assays to detect these mutations have been developed. Early versions of these assays have been used in research. This review summarizes the principles underlying each assay and discusses strategic needs for their incorporation into the management of HIV infection.

Indexed as

Point-of-Care TestingAnti-HIV AgentsDrug Resistance, ViralHIVHIV InfectionsHumansReverse Transcriptase Polymerase Chain ReactionAnti-HIV Agentsdrug resistanceHIVpoint-of-care tests

Identifiers

PMID29040621
PMCPMC5853236

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.