ArticleCerebral cortex (New York, N.Y. : 1991)2017
Fractionating the Neurocognitive Mechanisms Underlying Working Memory: Independent Effects of Dopamine and Parkinson's Disease.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Methylphenidate undermines or enhances divergent creativity depending on baseline dopamine synthesis capacity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- A task-aligned multimodal machine learning framework for studying working memory dysfunction in Parkinson's disease.Cognitive neurodynamics · 2026Article
- Working memory filtering at encoding and maintenance in healthy ageing, Alzheimer's and Parkinson's disease.Scientific reports · 2025Article
- Selective Effects of Substantia Nigra and Locus Coeruleus Degeneration on Cognition in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- State-dependent memory mechanisms insights from neural circuits and clinical implications.Frontiers in cellular neuroscience · 2025Review
- Article
- Balancing excitation and inhibition: The role of neural network dynamics in working memory gating.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Effects of cholinesterase inhibition on attention and working memory in Lewy body dementias.Brain communications · 2023Article
- Dopaminergic medication normalizes aberrant cognitive control circuit signalling in Parkinson's disease.Brain : a journal of neurology · 2022Article
- Systematic Review of the Longitudinal Sensitivity of Precision Tasks in Visual Working Memory.Vision (Basel, Switzerland) · 2022Review
- A dopamine gradient controls access to distributed working memory in the large-scale monkey cortex.Neuron · 2021Article
- Dopamine effects on memory load and distraction during visuospatial working memory in cognitively normal Parkinson's disease.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2021Article
- Dissociable effects of age and Parkinson's disease on instruction-based learning.Brain communications · 2021Article
- A new toolbox to distinguish the sources of spatial memory error.Journal of vision · 2020Article
- Different patterns of short-term memory deficit in Alzheimer's disease, Parkinson's disease and subjective cognitive impairment.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- Abnormal distraction and load-specific connectivity during working memory in cognitively normal Parkinson's disease.Human brain mapping · 2020Article
- Dopamine affects short-term memory corruption over time in Parkinson's disease.NPJ Parkinson's disease · 2019Article
- Effects of Parkinson's disease and dopamine on digit span measures of working memory.Psychopharmacology · 2018Article
- Ignoring versus updating in working memory reveal differential roles of attention and feature binding.Cortex; a journal devoted to the study of the nervous system and behavior · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Deficits in working memory (WM) in Parkinson's disease (PD) are often considered to be secondary to dopaminergic depletion. However, the neurocognitive mechanisms by which dopamine causes these deficits remain highly contested, and PD is now also known to be associated with nondopaminergic pathology. Here, we examined how PD and dopaminergic medication modulate three components of WM: maintenance over time, updating contents with new information and making memories distracter-resistant. Compared with controls, patients were disproportionately impaired when retaining information for longer durations. By applying a probabilistic model, we were able to reveal that the source of this error was selectively due to precision of memory representations degrading over time. By contrast, replenishing dopamine levels in PD improved executive control over both the ability to ignore and update, but did not affect maintenance of information across time. This was due to a decrease in guess responses, consistent with the view that dopamine serves to prevent WM representations being corrupted by irrelevant information, but has no impact on information decay. Cumulatively, these results reveal a dissociation in the neural mechanisms underlying poor WM: whereas dopamine reduces interference, nondopaminergic systems in PD appear to modulate processes that prevent information decaying more quickly over time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.