ArticleCerebral cortex (New York, N.Y. : 1991)2018
Age-Related Changes in Temporal Processing of Rapidly-Presented Sound Sequences in the Macaque Auditory Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Parallel Age-Related Cochlear Neural Degeneration and Cortical Gain Adaptation in Normal-Hearing Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Aging in the Primary Auditory Cortex.Journal of the Association for Research in Otolaryngology : JARO · 2026Review
- Decoding of frequency-modulated sweeps by core and belt neurons in the alert macaque auditory cortex.Journal of neurophysiology · 2025Article
- Long-term training alters response dynamics in the aging auditory cortex.Hearing research · 2024Article
- BOLD fMRI responses to amplitude-modulated sounds across age in adult listeners.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Aging process and central auditory pathway: a study based on auditory brainstem evoked potential and frequency-following response.Einstein (Sao Paulo, Brazil) · 2022Article
- Hearing loss and brain plasticity: the hyperactivity phenomenon.Brain structure & function · 2021Review
- Cortical Responses to the Amplitude Envelopes of Sounds Change with Age.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Impoverished Inhibitory Control Exacerbates Multisensory Impairments in Older Fallers.Frontiers in aging neuroscience · 2021Article
- Brain Frequency-Specific Changes in the Spontaneous Neural Activity Are Associated With Cognitive Impairment in Patients With Presbycusis.Frontiers in aging neuroscience · 2021Article
- Auditory and Visual System White Matter Is Differentially Impacted by Normative Aging in Macaques.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Objective evidence of temporal processing deficits in older adults.Hearing research · 2020Review
- Exaggerated cortical representation of speech in older listeners: mutual information analysis.Journal of neurophysiology · 2020Article
- Article
- Age-related changes in sound onset and offset intensity coding in auditory cortical fields A1 and CL of rhesus macaques.Journal of neurophysiology · 2020Article
- Effects of Ketamine Administration on Auditory Information Processing in the Neocortex of Nonhuman Primates.Frontiers in psychiatry · 2020Article
- Top-down or bottom up: decreased stimulus salience increases responses to predictable stimuli of auditory thalamic neurons.The Journal of physiology · 2019Article
- The effects of aging on auditory cortical function.Hearing research · 2018Review
- Presbycusis Disrupts Spontaneous Activity Revealed by Resting-State Functional MRI.Frontiers in behavioral neuroscience · 2018Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The mammalian auditory cortex is necessary to resolve temporal features in rapidly-changing sound streams. This capability is crucial for speech comprehension in humans and declines with normal aging. Nonhuman primate studies have revealed detrimental effects of normal aging on the auditory nervous system, and yet the underlying influence on temporal processing remains less well-defined. Therefore, we recorded from the core and lateral belt areas of auditory cortex when awake young and old monkeys listened to tone-pip and noise-burst sound sequences. Elevated spontaneous and stimulus-driven activity were the hallmark characteristics in old monkeys. These old neurons showed isomorphic-like discharge patterns to stimulus envelopes, though their phase-locking was less precise. Functional preference in temporal coding between the core and belt existed in the young monkeys but was mostly absent in the old monkeys, in which old belt neurons showed core-like response profiles. Finally, the analysis of population activity patterns indicated that the aged auditory cortex demonstrated a homogenous, distributed coding strategy, compared to the selective, sparse coding strategy observed in the young monkeys. Degraded temporal fidelity and highly-responsive, broadly-tuned cortical responses could underlie how aged humans have difficulties to resolve and track dynamic sounds leading to speech processing deficits.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.