ArticlePLoS neglected tropical diseases2017
Serological and spatial analysis of alphavirus and flavivirus prevalence and risk factors in a rural community in western Kenya.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Characterizing dengue transmission in rural areas: A systematic review.PLoS neglected tropical diseases · 2023Pooled it
- Epidemiology of floods in sub-Saharan Africa: a systematic review of health outcomes.BMC public health · 2022Pooled it
- Chikungunya fever in Africa: a systematic review.Pathogens and global health · 2020Pooled it
- Sociodemographic and ecological factors associated with malaria and malaria recurrence risk in children in Msambweni, Kwale County, Kenya.Malaria journal · 2025Article
- Risk factors associated with dengue and chikungunya seroprevalence and seroconversion among urban populations in western and coastal Kenya.PLoS neglected tropical diseases · 2025Article
- Predicting the ecological niches ofFrontiers in tropical diseases · 2025Article
- Temporal Variation and Human Host Predominance inPathogens (Basel, Switzerland) · 2025Article
- Comparison of unmanned aerial vehicle imaging to ground truth walkthroughs for identifying and classifying trash sites serving as potential Aedes aegypti breeding grounds.Parasites & vectors · 2025Article
- Exposure to Dengue Virus During Pregnancy: Incidence and Impact on Maternal and Child Outcomes.The American journal of tropical medicine and hygiene · 2025Article
- Antibiotic prescribing patterns at outpatient clinics in Western and Coastal Kenya.PLOS global public health · 2025Article
- Article
- Understanding the factors contributing to dengue virus and chikungunya virus seropositivity and seroconversion among children in Kenya.PLoS neglected tropical diseases · 2024Article
- Effects of climate change and human activities on vector-borne diseases.Nature reviews. Microbiology · 2024Review
- Current Epidemiological Status of Chikungunya Virus Infection in East Africa: A Systematic Review and Meta-Analysis.Journal of tropical medicine · 2024Review
- Interaction of Human Behavioral Factors Shapes the Transmission of Arboviruses byPathogens (Basel, Switzerland) · 2023Review
- EDIII-Fc induces protective immune responses against the Zika virus in mice and rhesus macaque.PLoS neglected tropical diseases · 2023Article
- Seroprevalence of Dengue and Chikungunya Virus Infections in Children Living in Sub-Saharan Africa: Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2023Review
- The Importance of Including Non-Household Environments in Dengue Vector Control Activities.Viruses · 2023Article
- Article
- Spatiotemporal overlapping of dengue, chikungunya, and malaria infections in children in Kenya.BMC infectious diseases · 2023Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
Alphaviruses, such as chikungunya virus, and flaviviruses, such as dengue virus, are (re)-emerging arboviruses that are endemic in tropical environments. In Africa, arbovirus infections are often undiagnosed and unreported, with febrile illnesses often assumed to be malaria. This cross-sectional study aimed to characterize the seroprevalence of alphaviruses and flaviviruses among children (ages 5-14, n = 250) and adults (ages 15 ≥ 75, n = 250) in western Kenya. Risk factors for seropositivity were explored using Lasso regression. Overall, 67% of participants showed alphavirus seropositivity (CI95 63%-70%), and 1.6% of participants showed flavivirus seropositivity (CI95 0.7%-3%). Children aged 10-14 were more likely to be seropositive to an alphavirus than adults (p < 0.001), suggesting a recent transmission period. Alphavirus and flavivirus seropositivity was detected in the youngest participants (age 5-9), providing evidence of inter-epidemic transmission. Demographic variables that were significantly different amongst those with previous infection versus those without infection included age, education level, and occupation. Behavioral and environmental variables significantly different amongst those in with previous infection to those without infection included taking animals for grazing, fishing, and recent village flooding. Experience of recent fever was also found to be a significant indicator of infection (p = 0.027). These results confirm alphavirus and flavivirus exposure in western Kenya, while illustrating significantly higher alphavirus transmission compared to previous studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.