ArticleVector borne and zoonotic diseases (Larchmont, N.Y.)2018
Recommendations for Laboratory Containment and Management of Gene Drive Systems in Arthropods.
Article in Vector borne and zoonotic diseases (Larchmont, N.Y.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The ethics of genome editing in non-human animals: a systematic review of reasons reported in the academic literature.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Pooled it
- Chlorination Is Ineffective at Eliminating Insects from Wastewater: A Case Study UsingInsects · 2025Article
- Anti-CRISPR Anopheles mosquitoes inhibit gene drive spread under challenging behavioural conditions in large cages.Nature communications · 2024Article
- CRISPR/Cas9-based split homing gene drive targetingProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Infravec2 guidelines for the design and operation of containment level 2 and 3 insectaries in Europe.Pathogens and global health · 2023Article
- Requirements for market entry of gene drive-modified mosquitoes for control of vector-borne diseases: analogies to other biologic and biotechnology products.Frontiers in bioengineering and biotechnology · 2023Review
- Molecular characterization and genetic authentication assay for Anopheles 'hemocyte-like' cell lines 4a-3A and 4a-3B.Parasites & vectors · 2022Article
- A mass rearing cost calculator for the control of Culex quinquefasciatus in Hawai'i using the incompatible insect technique.Parasites & vectors · 2022Article
- Containment Practices for Arthropods Modified with Engineered Transgenes Capable of Gene Drive Addendum 1 to the Arthropod Containment Guidelines, Version 3.2.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2022Article
- Preparing an Insectary in Burkina Faso to Support Research in Genetic Technologies for Malaria Control.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2022Article
- Demystifying the Risk Assessment Process for Laboratory-Based Experiments Utilizing Invasive Genetic Elements: It Is More Than Gene Drive.Applied biosafety : journal of the American Biological Safety Association · 2021Article
- Article
- Making gene drive biodegradable.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi.Nature communications · 2020Article
- Adequacy and sufficiency evaluation of existing EFSA guidelines for the molecular characterisation, environmental risk assessment and post-market environmental monitoring of genetically modified insects containing engineered gene drives.EFSA journal. European Food Safety Authority · 2020Article
- A Cross-Sectional Survey of Biosafety Professionals Regarding Genetically Modified Insects.Applied biosafety : journal of the American Biological Safety Association · 2020Article
- Review
- Providing a policy framework for responsible gene drive research: an analysis of the existing governance landscape and priority areas for further research.Wellcome open research · 2020Article
- Experimental population modification of the malaria vector mosquito, Anopheles stephensi.PLoS genetics · 2019Article
- Considerations for the governance of gene drive organisms.Pathogens and global health · 2018Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Versatile molecular tools for creating driving transgenes and other invasive genetic factors present regulatory, ethical, and environmental challenges that should be addressed to ensure their safe use. In this article, we discuss driving transgenes and invasive genetic factors that can potentially spread after their introduction into a small proportion of individuals in a population. The potential of invasive genetic factors to increase their number in natural populations presents challenges that require additional safety measures not provided by previous recommendations regarding accidental release of arthropods. In addition to providing physical containment, invasive genetic factors require greater attention to strain management, including their distribution and identity confirmation. In this study, we focus on insects containing such factors with recommendations for investigators who are creating them, institutional biosafety committees charged with ensuring safety, funding agencies providing support, those managing insectaries handling these materials who are responsible for containment, and other persons who will be receiving insects-transgenic or not-from these facilities. We give specific examples of efforts to modify mosquitoes for mosquito-borne disease control, but similar considerations are relevant to other arthropods that are important to human health, the environment, and agriculture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.