ArticleInternational braz j urol : official journal of the Brazilian Society of Urology
Which is best method for instillation of topical therapy to the upper urinary tract? An in vivo porcine study to evaluate three delivery methods.
Article in International braz j urol : official journal of the Brazilian Society of Urology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Bacillus Calmette-Guérin therapy in the management of upper tract urothelial carcinoma in-situ: a systematic review.Translational andrology and urology · 2026Review
- Patterns of adjuvant intracavitary instillation and recurrence after endoscopic management of upper tract urothelial carcinoma.World journal of urology · 2026Article
- A Case of Complete Remission of Bilateral Upper Tract Carcinoma In Situ Following Retrograde Bacillus Calmette-Guérin (BCG) Instillation via Open-Ended Ureteral Catheters After Failure Using Double-J Stents.IJU case reports · 2025Article
- The Utility of Intraluminal Therapies in Upper Tract Urothelial Carcinoma: A Narrative Review.Cancers · 2024Review
- Adjuvant intraluminal therapies for upper tract urothelial carcinoma.Translational andrology and urology · 2023Review
- The Role of Local Agents for the Treatment of Localized Upper Tract Urothelial Carcinoma: A Review of the Current Evidence.Bladder cancer (Amsterdam, Netherlands) · 2023Review
- Review
- New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing.International journal of environmental research and public health · 2020Review
- Optimal Management of Upper Tract Urothelial Carcinoma: Current Perspectives.OncoTargets and therapy · 2020Review
- UGN-101 (mitomycin gel): a novel treatment for low-grade upper tract urothelial carcinoma.Therapeutic advances in medical oncology · 2020Review
- Consultation on UTUC, Stockholm 2018: aspects of treatment.World journal of urology · 2019Review
- Instrumental dead space and proximal working channel connector design in flexible ureteroscopy: a new concept.Therapeutic advances in urologyArticle
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare the staining intensity of the upper urinary tract (UUT) urothelium among three UUT delivery methods in an in vivo porcine model. MATERIALS AND
methodsA fluorescent dye solution (indigo carmine) was delivered to the UUT via three different methods: antegrade perfusion, vesico-ureteral reflux via indwelling ureteric stent and retrograde perfusion via a 5F open-ended ureteral catheter. Twelve renal units were tested with 4 in each method. After a 2-hour delivery time, the renal-ureter units were harvested en bloc. Time from harvesting to analysis was also standardised to be 2 hours in each arm. Three urothelium samples of the same weight and size were taken from each of the 6 pre-defined points (upper pole, mid pole, lower pole, renal pelvis, mid ureter and distal ureter) and the amount of fluorescence was measured with a spectrometer.
resultsThe mean fluorescence detected at all 6 predefined points of the UUT urothelium was the highest for the retrograde method. This was statistically significant with p-value less than <0.05 at all 6 points.
conclusionsRetrograde infusion of UUT by an open ended ureteral catheter resulted in highest mean fluorescence detected at all 6 pre-defined points of the UUT urothelium compared to antegrade infusion and vesico-ureteral reflux via indwelling ureteric stents indicating retrograde method ideal for topical therapy throughout the UUT urothelium. More clinical studies are needed to demonstrate if retrograde method could lead to better clinical outcomes compared to the other two methods.
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