Evidence map›Paper›PMID 29039819›Full record

ReviewDiagnostics (Basel, Switzerland)2017

Single Domain Antibodies as New Biomarker Detectors.

Chiuan Herng Leow, Katja Fischer, Chiuan Yee Leow, Qin Cheng, Candy Chuah, James McCarthy

Open access · goldAbstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Signal-Amplified Nanobiosensors for Virus Detection Using Advanced Nanomaterials.Advances in biochemical engineering/biotechnology · 2024
    Review
  5. Review
  6. Large-Scale Production of Anti-RNase A VHH Expressed inCurrent issues in molecular biology · 2023
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Chiuan Herng LeowInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, Penang 11800, Malaysia. herng.leow@usm.my.ORCID 0000-0003-0849-428X
Katja FischerBacterial Pathogenesis and Scabies Laboratory, QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia. katja.fischer@qimrberghofer.edu.au.
Chiuan Yee LeowInstitute for Research in Molecular Medicine, Universiti Sains Malaysia, Kelantan 16150, Malaysia. yee.leow@usm.my.
Qin ChengDepartment of Drug Resistance and Diagnostics, Australian Army Malaria Institute, Brisbane 4051, Australia. qin.cheng@defence.gov.au.ORCID 0000-0001-7776-4437
Candy ChuahDepartment of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan 16150, Malaysia. chuahcandy@usm.my.
James McCarthyClinical Tropical Medicine Laboratory, QIMR Berghofer Medical Research Institute, Brisbane 4029, Australia. james.mccarthy@qimrberghofer.edu.au.
Universiti Sains Malaysia · MYQIMR Berghofer Medical Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomarkers are defined as indicators of biological processes, pathogenic processes, or pharmacological responses to a therapeutic intervention. Biomarkers have been widely used for early detection, prediction of response after treatment, and for monitoring the progression of diseases. Antibodies represent promising tools for recognition of biomarkers, and are widely deployed as analytical tools in clinical settings. For immunodiagnostics, antibodies are now exploited as binders for antigens of interest across a range of platforms. More recently, the discovery of antibody surface display and combinatorial chemistry techniques has allowed the exploration of new binders from a range of animals, for instance variable domains of new antigen receptors (V

Indexed as

antibodybiomarkercamelids VHHdiagnosticsshark VNARsingle domain antibody (sdAbs)

Identifiers

PMID29039819
PMCPMC5745390
OpenAlexW2765592911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.