ArticleMolecular medicine reports2017
Caveolin‑1 regulates oxidative stress‑induced senescence in nucleus pulposus cells primarily via the p53/p21 signaling pathway in vitro.
Article in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Biomaterials for intervertebral disc regeneration: Niche reprogramming, precision therapeutics, and structural reconstruction.Bioactive materials · 2027Review
- Upregulation of MYBL2 ameliorates senescence of nucleus pulposus cells in degenerative intervertebral discs based on RNA-sequencing analysis.Journal of molecular histology · 2026Article
- The FGF13-Caveolin-1 Axis: A Key Player in the Pathogenesis of Doxorubicin- and D-Galactose-Induced Premature Cardiac Aging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Review
- Cellular Senescence in Intervertebral Disc Aging and Degeneration: Molecular Mechanisms and Potential Therapeutic Opportunities.Biomolecules · 2023Review
- Effects of periodic mechanical stress on cytoskeleton dependent lipid raft-induced integrin ɑ1 activation in rat nucleus pulposus cells.Journal of molecular histology · 2023Article
- BRD4 Inhibition Suppresses Senescence and Apoptosis of Nucleus Pulposus Cells by Inducing Autophagy during Intervertebral Disc Degeneration: An In Vitro and In Vivo Study.Oxidative medicine and cellular longevity · 2022Article
- Low-intensity pulsed ultrasound ameliorates angiotensin II-induced cardiac fibrosis by alleviating inflammation via a caveolin-1-dependent pathway.Journal of Zhejiang University. Science. B · 2021Article
- Caveolin-1 Regulates Cellular Metabolism: A Potential Therapeutic Target in Kidney Disease.Frontiers in pharmacology · 2021Review
- Icariin modulates the sirtuin/NF‑κB pathway and exerts anti‑aging effects in human lung fibroblasts.Molecular medicine reports · 2020Article
- Positive feedback in Cav-1-ROS signalling in PSCs mediates metabolic coupling between PSCs and tumour cells.Journal of cellular and molecular medicine · 2020Article
- Caveolin-1, a master regulator of cellular senescence.Cancer metastasis reviews · 2020Review
- Involvement of the Endocrine-Disrupting Chemical Bisphenol A (BPA) in Human Placentation.Journal of clinical medicine · 2020Article
- Syndecan-4 is a Novel Therapeutic Target for Intervertebral Disc Degeneration via Suppressing JNK/p53 Pathway.International journal of biological sciences · 2020Article
- β‑catenin signalling inhibits cartilage endplate chondrocyte homeostasis in vitro.Molecular medicine reports · 2019Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have indicated that cellular senescence is a critical underlying mechanism of intervertebral disc degeneration. However, the precise mechanism by which cellular senescence accelerates disc degeneration has not been fully elucidated. Caveolin‑1 has recently emerged as an important regulator of cellular senescence. Therefore, the aim of the present study was to investigate whether caveolin‑1 is involved in nucleus pulposus (NP) cellular senescence during oxidative stress. PCR was used to detect caveolin‑1 mRNA expression and protein expression was detected by western blotting. Caveolin‑1 expression at the mRNA and protein levels was markedly increased following treatment with tert‑butyl hydroperoxide, and an increase in premature senescence was observed, as determined by senescence‑associated β‑galactosidase staining and the decline of cellular proliferative ability. In addition, caveolin‑1 gene expression was successfully knocked down by lentivirus‑mediated RNA interference, which exerted a protective effect against the cellular senescence induced by oxidative stress. Notably, p53 and p21 protein expression, though not p16 protein expression, decreased with caveolin‑1 silencing. The results suggested that caveolin‑1 may be involved in NP cellular senescence during oxidative stress in vitro, mainly via the p53/p21 signaling pathway. Thus, caveolin‑1 may represent a novel therapeutic target for the prevention of intervertebral disc degeneration.
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