Evidence map›Paper›PMID 29039142›Full record

ReviewCurrent neurology and neuroscience reports2017

Microbiota-Brain-Gut Axis and Neurodegenerative Diseases.

Eamonn M M Quigley

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Current neurology and neuroscience reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06039267 (Brain Health & the Microbiome), which is not on this map. Cited by 411 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
411citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06039267 completednot on this mapstarted 2023, after this paper: background citation

Brain Health & the Microbiome: A Proof-of-Concept Study in Patients With Mild Cognitive Impairment

TypeobservationalSponsorGeorge Washington UniversityRan2023 to 2025Enrolled44ConditionsMild Cognitive Impairment, Mild Dementia, Alzheimer Disease 1ArmsGut Microbiome Testing
3 · Its place in the literature

Who cites it

411 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  4. Nutrients · 2025
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  9. Efficacy and Safety ofNutrients · 2025
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351 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Eamonn M M QuigleyLynda K and David M Underwood Center for Digestive Disorders, Division of Gastroenterology and Hepatology, Houston Methodist Hospital and Weill Cornell Medical College, 6550 Fannin St, SM 1201, Houston, TX, 77030, USA. equigley@houstonmethodist.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThe purposes of this review were as follows: first, to provide an overview of the gut microbiota and its interactions with the gut and the central nervous system (the microbiota-gut-brain axis) in health, second, to review the relevance of this axis to the pathogenesis of neurodegenerative diseases, such as Parkinson's disease, and, finally, to assess the potential for microbiota-targeted therapies. RECENT

findingsWork on animal models has established the microbiota-gut-brain axis as a real phenomenon; to date, the evidence for its operation in man has been limited and has been confronted by considerable logistical challenges. Animal and translational models have incriminated a disturbed gut microbiota in a number of CNS disorders, including Parkinson's disease; data from human studies is scanty. While a theoretical basis can be developed for the use of microbiota-directed therapies in neurodegenerative disorders, support is yet to come from high-quality clinical trials. In theory, a role for the microbiota-gut-brain axis is highly plausible; clinical confirmation is awaited.

Indexed as

Molecular Targeted TherapyAnimalsBrainGastrointestinal MicrobiomeHumansNeurodegenerative DiseasesAlzheimer’s diseaseAntibioticsFecal microbiota transplantationGut-brain axisMicrobiomeMicrobiotaNeurodegenerative diseasesParkinson’s diseaseProbiotics

Identifiers

PMID29039142

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.