Evidence map›Paper›PMID 29039117›Full record

ArticleCerebellum (London, England)2018

In Vivo Dentate Nucleus Gamma-aminobutyric Acid Concentration in Essential Tremor vs. Controls.

Elan D Louis, Nora Hernandez, Jonathan P Dyke, Ruoyun E Ma, Ulrike Dydak

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebellum (London, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Pathophysiological Role of Primary Motor Cortex in Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  5. Review
  6. Article
  7. Essential tremor: Clinical perspectives and pathophysiology.Journal of the neurological sciences · 2022
    Review
  8. Article
  9. Is the inferior olive central to essential tremor? Yes.International review of neurobiology · 2022
    Article
  10. Is essential tremor a disorder of primary GABA dysfunction? Yes.International review of neurobiology · 2022
    Review
  11. Review
  12. The Molecular Neuroimaging of Tremor.Current neurology and neuroscience reports · 2021
    Review
  13. Review
  14. Article
  15. The Role of the Cerebellum in Tremor - Evidence from Neuroimaging.Tremor and other hyperkinetic movements (New York, N.Y.) · 2021
    Review
  16. Structural Correlates of the Sensorimotor Cerebellum in Parkinson's Disease and Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2020
    Article
  17. Article
  18. Review
  19. [Pathophysiology of tremor].Der Nervenarzt · 2018
    Review
  20. Animal Models of Tremor: Relevance to Human Tremor Disorders.Tremor and other hyperkinetic movements (New York, N.Y.) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Elan D LouisDepartment of Neurology, Yale School of Medicine, Yale University, LCI 710, 15 York Street, PO Box 208018, New Haven, CT, 06520-8018, USA. elan.louis@yale.edu.
Nora HernandezDepartment of Neurology, Yale School of Medicine, Yale University, LCI 710, 15 York Street, PO Box 208018, New Haven, CT, 06520-8018, USA.
Jonathan P DykeDepartment of Radiology, Weill Cornell Medical College, New York, NY, USA.
Ruoyun E MaSchool of Health Sciences, Purdue University, West Lafayette, IN, USA.
Ulrike DydakSchool of Health Sciences, Purdue University, West Lafayette, IN, USA.
Yale University · USCornell University · USIndiana University – Purdue University Indianapolis · USIndiana University School of Medicine

Funding

PATHOLOG-OMICS - ESSENTIAL TREMOR IN THE BROADER CONTEXT OF NEURODEGENERATIONR01NS088257 · NINDS · YALE UNIVERSITY · PI FAUST, PHYLLIS L, LOUIS, ELAN D · 2015 to 2019
$3.3M
in Vivo Quantification of Cerebellar GABA and NAA in Essential TremorR01NS085136 · NINDS · YALE UNIVERSITY · PI MATUSKEY, DAVID A · 2013 to 2017
$3.3M
National Institute of Neurological Disorders and Stroke NINDS R01 NS085136NINDS NIH HHS R01 NS085136NINDS NIH HHS R01 NS088257
6 · The paper itself

Abstract

Despite its high prevalence, essential tremor (ET) is among the most poorly understood neurological diseases. The presence and extent of Purkinje cell (PC) loss in ET is the subject of controversy. PCs are a major storehouse of central nervous system gamma-aminobutyric acid (GABA), releasing GABA at the level of the dentate nucleus. It is therefore conceivable that cerebellar dentate nucleus GABA concentration could be an in vivo marker of PC number. We used in vivo CONTROLS: One interpretation of the finding is that it does not support the existence of PC loss in ET; however, an alternative interpretation is the observed pattern could be due to the effects of terminal sprouting in ET (i.e., collateral sprouting from surviving PCs making up for the loss of GABA-ergic terminals from PC degeneration). Further research is needed.

Indexed as

AgedAged, 80 and overCerebellar NucleiEssential TremorFemalegamma-Aminobutyric AcidHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedRetrospective StudiesTritiumgamma-Aminobutyric AcidTritiumCerebellumDentate nucleusEssential tremorGamma-aminobutyric acidMagnetic resonance spectroscopyNeurodegenerationPurkinje cell

Identifiers

PMID29039117
PMCPMC5851820
OpenAlexW2766563739

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.