ArticleBiomechanics and modeling in mechanobiology2018
Layer-dependent role of collagen recruitment during loading of the rat bladder wall.
Article in Biomechanics and modeling in mechanobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
- Quantifying Local Strain Field and Deformation in Active Contraction of Bladder Using a Pretrained Transformer Model: A Speckle-Free Approach.Results in engineering · 2026Article
- Cases - Ehlers-Danlos syndromes: Review on the urologic implications.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2026Article
- Load Transfer along Continuous Collagen Fibers Reduces the Importance of Wall Thickness Variations.ArXiv · 2025Article
- Elucidating the high compliance mechanism by which the urinary bladder fills under low pressures.Scientific reports · 2025Article
- Effect of Collagen Fiber Tortuosity Distribution on the Mechanical Response of Arterial Tissues.Journal of biomechanical engineering · 2025Article
- Direct measurements of collagen fiber recruitment in the posterior pole of the eye.Acta biomaterialia · 2024Article
- Aging and urinary control: Alterations in the brain-bladder axis.Aging cell · 2023Review
- Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell.Experimental eye research · 2023Article
- Value of multiphoton microscopy in uro-oncology: a narrative review.Translational andrology and urology · 2023Review
- Instant polarized light microscopy pi (IPOLπ) for quantitative imaging of collagen architecture and dynamics in ocular tissues.bioRxiv : the preprint server for biology · 2023Article
- Purine nucleoside phosphorylase as a target to treat age-associated lower urinary tract dysfunction.Nature reviews. Urology · 2022Review
- A constrained mixture-micturition-growth (CMMG) model of the urinary bladder: Application to partial bladder outlet obstruction (BOO).Journal of the mechanical behavior of biomedical materials · 2022Article
- Dog and human bladders have different neurogenic and nicotinic responses in inner versus outer detrusor muscle layers.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Functional and Immunofluorescence Evaluations of Vascular and Neural Integrities in Urinary Bladder of Streptozotocin-Induced Diabetic Mice.International neurourology journal · 2022Article
- Increased extracellular matrix stiffness accompanies compromised bladder function in a murine model of radiation cystitis.Acta biomaterialia · 2022Article
- Remodeling of extracellular matrix in the urinary bladder of paraplegic rats results in increased compliance and delayed fiber recruitment 16 weeks after spinal cord injury.Acta biomaterialia · 2022Article
- The Release of 24 h Infravesical Obstruction in Mice: Changes in Molecular, Morphological, and Functional Parameters for 14-Day Observation.Frontiers in medicine · 2022Article
- The Significance of Biomechanics and Scaffold Structure for Bladder Tissue Engineering.International journal of molecular sciences · 2021Review
- Osr1 Is Required for Mesenchymal Derivatives That Produce Collagen in the Bladder.International journal of molecular sciences · 2021Article
- Experimental long-term diabetes mellitus alters the transcriptome and biomechanical properties of the rat urinary bladder.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
In this work, we re-evaluated long-standing conjectures as to the source of the exceptionally large compliance of the bladder wall. Whereas these conjectures were based on indirect measures of loading mechanisms, in this work we take advantage of advances in bioimaging to directly assess collagen fibers and wall architecture during biaxial loading. A custom biaxial mechanical testing system compatible with multiphoton microscopy was used to directly measure the layer-dependent collagen fiber recruitment in bladder tissue from 9 male Fischer rats (4 adult and 5 aged). As for other soft tissues, the bladder loading curve was exponential in shape and could be divided into toe, transition and high stress regimes. The relationship between collagen recruitment and loading curves was evaluated in the context of the inner (lamina propria) and outer (detrusor smooth muscle) layers. The large extensibility of the bladder was found to be possible due to folds in the wall (rugae) that provide a mechanism for low resistance flattening without any discernible recruitment of collagen fibers throughout the toe regime. For more extensible bladders, as the loading extended into the transition regime, a gradual coordinated recruitment of collagen fibers between the lamina propria layer and detrusor smooth muscle layer was found. A second important finding was that wall extensibility could be lost by premature recruitment of collagen in the outer wall that cut short the toe region. This change was correlated with age. This work provides, for the first time, a mechanistic understanding of the role of collagen recruitment in determining bladder extensibility and capacitance.
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