Evidence map›Paper›PMID 29038971›Full record

SynthesisNeurocritical care2017

The Implementation of Targeted Temperature Management: An Evidence-Based Guideline from the Neurocritical Care Society.

Lori Kennedy Madden, Michelle Hill, Teresa L May, Theresa Human, Mary McKenna Guanci, Judith Jacobi, Melissa V Moreda, Neeraj Badjatia

Registry-linked trialOpen access · bronzeAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Neurocritical care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07096687 (Targeted Temperature Management for Neuroprotection in Acute Ischemic Stroke), which is not on this map. Cited by 58 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 4 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07096687 narecruitingnot on this mapstarted 2025, after this paper: background citation

Targeted Temperature Management for Neuroprotection in Acute Ischemic Stroke: A Randomized Controlled Pilot Trial

TypeinterventionalSponsorAzienda Usl di BolognaRan2025 to 2027Enrolled22ConditionsIschemic StrokeArmsTargeted Temperature Management with CB240_Aurora, Standard of care Temperature treatment
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 4 syntheses or guidelines pooled it, 143 citations in OpenAlex.

  1. Pooled it
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  8. Temperature control in acute brain injury.Intensive care medicine · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 1 country.

Lori Kennedy MaddenUniversity of California Davis, Sacramento, CA, USA. lkmadden@ucdavis.edu.ORCID http://orcid.org/0000-0001-9179-4202
Michelle HillRiverside Methodist Hospital, Columbus, OH, USA.
Teresa L MayMaine Medical Center, Portland, ME, USA.
Theresa HumanBarnes Jewish Hospital, Washington University, Saint Louis, MO, USA.
Mary McKenna GuanciMassachusetts General Hospital, Boston, MA, USA.
Judith JacobiIndiana University Health Methodist Hospital, Indianapolis, IN, USA.
Melissa V MoredaDuke Raleigh Hospital, Raleigh, NC, USA.
Neeraj BadjatiaUniversity of Maryland, Baltimore, MD, USA.
Barnes-Jewish Hospital · USDuke Raleigh Hospital · USMaine Medical Center · USMassachusetts General Hospital · USMethodist Hospital · USRiverside Methodist Hospital · USUniversity of California System · USUniversity of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTargeted temperature management (TTM) is often used in neurocritical care to minimize secondary neurologic injury and improve outcomes. TTM encompasses therapeutic hypothermia, controlled normothermia, and treatment of fever. TTM is best supported by evidence from neonatal hypoxic-ischemic encephalopathy and out-of-hospital cardiac arrest, although it has also been explored in ischemic stroke, traumatic brain injury, and intracranial hemorrhage patients. Critical care clinicians using TTM must select appropriate cooling techniques, provide a reasonable rate of cooling, manage shivering, and ensure adequate patient monitoring among other challenges.

methodsThe Neurocritical Care Society recruited experts in neurocritical care, nursing, and pharmacotherapy to form a writing Committee in 2015. The group generated a set of 16 clinical questions relevant to TTM using the PICO format. With the assistance of a research librarian, the Committee undertook a comprehensive literature search with no back date through November 2016 with additional references up to March 2017.

resultsThe Committee utilized GRADE methodology to adjudicate the quality of evidence as high, moderate, low, or very low based on their confidence that the estimate of effect approximated the true effect. They generated recommendations regarding the implementation of TTM based on this systematic review only after considering the quality of evidence, relative risks and benefits, patient values and preferences, and resource allocation.

conclusionThis guideline is intended for neurocritical care clinicians who have chosen to use TTM in patient care; it is not meant to provide guidance regarding the clinical indications for TTM itself. While there are areas of TTM practice where clear evidence guides strong recommendations, many of the recommendations are conditional, and must be contextualized to individual patient and system needs.

Indexed as

Critical CareEvidence-Based MedicineHumansHypothermia, InducedNervous System DiseasesPractice Guidelines as TopicSocieties, MedicalComplicationsControlled normothermiaFever treatmentGRADE methodologyGuidelineHypothermiaImplementation guidelineMetabolismNormothermiaPatient managementShiveringSystematic reviewTargeted temperature managementTherapeutic hypothermia

Identifiers

PMID29038971
OpenAlexW2766930276

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.