Evidence map›Paper›PMID 29038827›Full record

ArticleWorld journal of surgery2018

Is Routine Intraoperative Contrast-Enhanced Ultrasonography Useful During Whole Liver Transplantation?

Nicolas Golse, Simone Santoni, Vincent Karam, Oriana Ciacio, Gabriella Pittau, Marc-Antoine Allard, Daniel Cherqui, Antonio Sa Cunha, René Adam, Denis Castaing and 1 more

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Article in World journal of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Nicolas GolseAP-HP Hôpital Paul-Brousse, Centre Hépato-Biliaire, 12 Avenue Paul Vaillant Couturier, 94800, Villejuif Cedex, France. nicolasgolse@me.com.
Simone SantoniAP-HP Hôpital Paul-Brousse, Centre Hépato-Biliaire, 12 Avenue Paul Vaillant Couturier, 94800, Villejuif Cedex, France.
Vincent KaramAP-HP Hôpital Paul-Brousse, Centre Hépato-Biliaire, 12 Avenue Paul Vaillant Couturier, 94800, Villejuif Cedex, France.
Oriana CiacioAP-HP Hôpital Paul-Brousse, Centre Hépato-Biliaire, 12 Avenue Paul Vaillant Couturier, 94800, Villejuif Cedex, France.
Gabriella PittauAP-HP Hôpital Paul-Brousse, Centre Hépato-Biliaire, 12 Avenue Paul Vaillant Couturier, 94800, Villejuif Cedex, France.
Marc-Antoine AllardAP-HP Hôpital Paul-Brousse, Centre Hépato-Biliaire, 12 Avenue Paul Vaillant Couturier, 94800, Villejuif Cedex, France.
Daniel CherquiAP-HP Hôpital Paul-Brousse, Centre Hépato-Biliaire, 12 Avenue Paul Vaillant Couturier, 94800, Villejuif Cedex, France.
Antonio Sa CunhaAP-HP Hôpital Paul-Brousse, Centre Hépato-Biliaire, 12 Avenue Paul Vaillant Couturier, 94800, Villejuif Cedex, France.
René AdamAP-HP Hôpital Paul-Brousse, Centre Hépato-Biliaire, 12 Avenue Paul Vaillant Couturier, 94800, Villejuif Cedex, France.
Denis CastaingAP-HP Hôpital Paul-Brousse, Centre Hépato-Biliaire, 12 Avenue Paul Vaillant Couturier, 94800, Villejuif Cedex, France.
Eric VibertAP-HP Hôpital Paul-Brousse, Centre Hépato-Biliaire, 12 Avenue Paul Vaillant Couturier, 94800, Villejuif Cedex, France.
Hôpital Paul-Brousse · FRUniversité Paris-Sud · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVascular complications following liver transplantation (LT) may result from technical deficiencies. Intraoperative diagnosis remains challenging but can prevent serious delayed complications. Intraoperative Doppler ultrasonography (IOUS) represents the gold standard for imaging, although it requires radiological skills. Contrast-enhanced ultrasonography has been reported during postoperative assessments, but never intraoperatively (CE-IOUS). The aim of this study was to assess the feasibility of routine CE-IOUS, to evaluate its impact on surgical strategy and its usefulness.

methodsAll 553 whole LTs performed in our tertiary centre between 01/2010 and 12/2014 were reviewed. We compared perioperative outcomes and long-term survival in IOUS (n = 370) versus CE-IOUS (n = 103) groups. Secondarily, the seven cases where the two imaging findings conflicted (CE+ Group) were matched 1:2 and compared with an exclusively IOUS procedure (CE- Group, n = 14) to assess the consequences of a specific CE-guided strategy.

resultsCE-IOUS assessments were successful in 100% of cases, without any adverse effects. Vascular complications and patient/graft survival rates were identical in the IOUS and CE-IOUS groups (p = 0.65, 0.95 and 0.86, respectively). CE-IOUS confirmed IOUS findings in 93% of cases (n = 96) and led to the realization of an additional procedure (median arcuate ligament lysis) and six conservative strategies despite poor arterial (n = 5) or venous flow (n = 1) under Doppler analysis. The CE+ and CE- groups presented statistically identical perioperative and long-term outcomes.

conclusionThis study demonstrated the feasibility of CE-IOUS during whole LT. However, we failed to demonstrate any advantages of CE-IOUS over IOUS. Therefore, IOUS currently remains the gold-standard imaging technique for the intraoperative assessment of vascular patency.

Indexed as

Intraoperative CareLiver TransplantationVascular PatencyContrast MediaFeasibility StudiesFemaleHumansLiver NeoplasmsMaleMiddle AgedUltrasonographyContrast Media

Identifiers

PMID29038827
OpenAlexW2765603274

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.