ArticleMediators of inflammation2017
Alteration of Inflammatory Mediators in the Upper and Lower Airways under Chronic Intermittent Hypoxia: Preliminary Animal Study.
Article in Mediators of inflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 27 citations in OpenAlex.
- Intermittent hypoxia drives lung microbiome-metabolome remodeling to create a pro-inflammatory landscape in murine OSAHS.Frontiers in microbiology · 2026Article
- Observational
- Review
- Exploring the pharmacological mechanisms for alleviating OSA: Adenosine A2A receptor downregulation of the PI3K/Akt/HIF‑1 pathway (Review).Biomedical reports · 2025Review
- STAT6 deficiency mitigates the severity of pulmonary arterial hypertension caused by chronic intermittent hypoxia by suppressing Th2-inducing cytokines.Respiratory research · 2025Article
- Temporal Dynamics of Fractional Exhaled Nitric Oxide (FeNO) During CPAP Therapy in Obstructive Sleep Apnea: A Prospective Follow-Up Study.Nature and science of sleep · 2025Article
- Knowledge and Attitudes Toward Obstructive Sleep Apnea Among Korean Pulmonologists: A Nationwide Survey.Cureus · 2024Article
- Association between triglyceride glucose-body mass index and obstructive sleep apnea: a study from NHANES 2015-2018.Frontiers in nutrition · 2024Review
- Intermittent hypoxia induces Th17/Treg imbalance in a murine model of obstructive sleep apnea.PloS one · 2024Article
- Associations among sleep-disordered breathing, sleep quality, and lung cancer in Korean patients.Sleep & breathing = Schlaf & Atmung · 2023Article
- Association of obstructive sleep apnea with cardiometabolic diseases and cardiovascular mortality.The clinical respiratory journal · 2023Article
- On the Relationship between Diabetes and Obstructive Sleep Apnea: Evolution and Epigenetics.Biomedicines · 2022Review
- Orexin-A Reverse Bone Mass Loss Induced by Chronic Intermittent Hypoxia Through OX1R-Nrf2/HIF-1α Pathway.Drug design, development and therapy · 2022Article
- Association Between Snoring and Diabetes Among Pre- and Postmenopausal Women.International journal of general medicine · 2022Article
- Deficiency in ST2 signaling ameliorates RSV-associated pulmonary hypertension.American journal of physiology. Heart and circulatory physiology · 2021Article
- The effect of apnea management on novel coronavirus infection: A study on patients with obstructive sleep apnea.Sleep health · 2021Article
- The role of reactive oxygen species in cognitive impairment associated with sleep apnea.Experimental and therapeutic medicine · 2020Article
- Novel coronavirus SARS-CoV-2 (Covid-19) dynamics inside the human body.Reviews in medical virology · 2020Review
- Attenuation of intermittent hypoxia-induced apoptosis and fibrosis in pulmonary tissues via suppression of ER stress activation.BMC pulmonary medicine · 2020Article
- Sleep Apnea, Obesity, and Disturbed Glucose Homeostasis: Epidemiologic Evidence, Biologic Insights, and Therapeutic Strategies.Current obesity reports · 2020Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe hypothesized that CIH may affect the upper airway immune system and aimed to verify whether CIH can induce airway inflammation in a murine obstructive sleep apnea (OSA) model.
methodsC57BL6 male mice were exposed to intermittent hypoxia (CIH group; 5 ~ 21% FiO
resultsWe determined the protein level of 24 different cytokines, chemokines, and inflammatory mediators. Among various cytokines, levels of IL-1
conclusionsCIH for 4 weeks altered the levels of inflammatory mediators in both the nose and lungs of mouse model. We suggest that the airway immune system may be deteriorated by CIH and allergic inflammation in the upper or lower airway could be worsened by sleep apnea.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.