Evidence map›Paper›PMID 29038592›Full record

ArticleScientific reports2017

In vivo imaging of lung inflammation with neutrophil-specific

Juan Pellico, Ana V Lechuga-Vieco, Elena Almarza, Andrés Hidalgo, Cristina Mesa-Nuñez, Irene Fernández-Barahona, Juan A Quintana, Juan Bueren, Jose A Enríquez, Jesús Ruiz-Cabello and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 53 citations in OpenAlex.

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  17. Retention ofACS infectious diseases · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Juan PellicoCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). C/Melchor Fernández-Almagro 3, 28029, Madrid, Spain.ORCID 0000-0003-2787-8641
Ana V Lechuga-ViecoCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). C/Melchor Fernández-Almagro 3, 28029, Madrid, Spain.
Elena AlmarzaDivision of Hematopoietic Innovative Therapies, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas/Centro de Investigación Biomédica en Red de Enfermedades Raras, 28040, Madrid, Spain.
Andrés HidalgoCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). C/Melchor Fernández-Almagro 3, 28029, Madrid, Spain.
Cristina Mesa-NuñezDivision of Hematopoietic Innovative Therapies, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas/Centro de Investigación Biomédica en Red de Enfermedades Raras, 28040, Madrid, Spain.
Irene Fernández-BarahonaCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). C/Melchor Fernández-Almagro 3, 28029, Madrid, Spain.
Juan A QuintanaCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). C/Melchor Fernández-Almagro 3, 28029, Madrid, Spain.
Juan BuerenDivision of Hematopoietic Innovative Therapies, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas/Centro de Investigación Biomédica en Red de Enfermedades Raras, 28040, Madrid, Spain.
Jose A EnríquezCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). C/Melchor Fernández-Almagro 3, 28029, Madrid, Spain.ORCID 0000-0002-3671-2961
Jesús Ruiz-CabelloCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). C/Melchor Fernández-Almagro 3, 28029, Madrid, Spain.ORCID 0000-0001-8681-5056
Fernando HerranzCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) and Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES). C/Melchor Fernández-Almagro 3, 28029, Madrid, Spain. fherranz@cnic.es.ORCID 0000-0002-3743-0050
Spanish National Centre for Cardiovascular Research · ESCentre for Biomedical Network Research on Rare Diseases · ESUniversidad Complutense de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In vivo detection and quantification of inflammation is a major goal in molecular imaging. Furthermore, cell-specific detection of inflammation would be a tremendous advantage in the characterization of many diseases. Here, we show how this goal can be achieved through the synergistic combination of nanotechnology and nuclear imaging. One of the most remarkable features of this hybrid approach is the possibility to tailor the pharmacokinetics of the nanomaterial-incorporated biomolecule and radionuclide. A good example of this approach is the covalent binding of a large amount of a neutrophil-specific, hydrophobic peptide on the surface of

Indexed as

AnimalsDisease Models, AnimalGallium RadioisotopesHematopoietic Stem CellsMiceMice, Inbred C57BLNanoparticlesNeutrophilsPneumoniaPositron-Emission TomographyRadioactive TracersGallium RadioisotopesRadioactive Tracers

Identifiers

PMID29038592
PMCPMC5643527
OpenAlexW2763785274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.