SynthesisScientific reports2017
Vitamin D and cognitive function: A Mendelian randomisation study.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis.PloS one · 2023Pooled it
- Impact of vitamin D on cognitive functions in healthy individuals: A systematic review in randomized controlled clinical trials.Frontiers in psychology · 2022Pooled it
- Vitamin D Supplementation and Cognition in Adults: A Systematic Review of Randomized Controlled Trials.CNS drugs · 2021Pooled it
- Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases-An Umbrella Review.Nutrients · 2020Pooled it
- Trial
- Independent Associations of Vitamin D Levels with Visceral Fat and Metabolic Age in Adults: A Retrospective Cross-Sectional Study.Metabolites · 2026Article
- Current state of nutritional psychiatry: A scoping review of randomized controlled trials.World journal of methodology · 2025Article
- Vitamin-mineral supplements and cognition among adults aged 65 and older: multiple cross-sectional population-based studies.European journal of nutrition · 2025Article
- The Interaction Between Cognitive Abilities and White Matter Hyperintensity Phenotypes: A Novel Perspective on Bidirectional Causality.Brain and behavior · 2025Article
- Indian ASD probands with 25(OH)D and vitamin D binding protein deficiency exhibited higher severity.Scientific reports · 2024Article
- Vitamin D and Cognitive Performance in Older Adults: A Cross-Sectional and Mendelian Randomization Study.Alpha psychiatry · 2024Article
- Development and Validation of Novel HPLC Methods for Quantitative Determination of Vitamin D3 in Tablet Dosage Form.Pharmaceuticals (Basel, Switzerland) · 2024Article
- The Influence of Vitamin D Status on Cognitive Ability in Patients with Bipolar Disorder and Healthy Controls.Nutrients · 2023Article
- Falsification of the instrumental variable conditions in Mendelian randomization studies in the UK Biobank.European journal of epidemiology · 2023Article
- Vitamin D Status Over Time and Cognitive Function in Norwegian Older Adults: A Prospective Cohort of the HUNT Study.The journal of nutrition, health & aging · 2023Article
- Exploring the Association between Vitamin D and Changes in Cognitive Function in Chilean Older Adults: Evidence from the ALEXANDROS Cohort Study.Journal of personalized medicine · 2022Article
- Can Nutrients and Dietary Supplements Potentially Improve Cognitive Performance Also in Esports?Healthcare (Basel, Switzerland) · 2022Review
- Efficacy of a novel proprietary dietary supplement (TRI 360Frontiers in psychiatry · 2022Article
- Analysis of hot trends in research on the association between vitamin D and cardiovascular disease.Frontiers in nutrition · 2022Article
- Most Effective Combination of Nutraceuticals for Improved Memory and Cognitive Performance in the House Cricket,Nutrients · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
49 authors.
Jane MaddockMRC Lifelong Health and Ageing at UCL, London, United Kingdom. jane.maddock@ucl.ac.uk.
Ang ZhouCentre for Population Health Research, Sansom Institute, University of South Australia, Adelaide, Australia.
Alana CavadinoPopulation, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
Elżbieta KuźmaUniversity of Exeter Medical School, Exeter, United Kingdom.
Yanchun BaoInstitute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.
Melissa C SmartInstitute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.
Kai-Uwe SaumDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ben SchöttkerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jorgen EngmannDepartment of Epidemiology and Public Health, University College London, London, United Kingdom.
Marie KjærgaardDivision of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.
Ville KarhunenCenter for Life Course Health Research, University of Oulu, Oulu, Finland.
Yiqiang ZhanDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Suvi P RovioResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Liisa BybergDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Jari LahtiDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Pedro Marques-VidalDepartment of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.ORCID 0000-0002-4548-8500
Abhijit SenDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Laura PernaDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Henrik SchirmerDepartment of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
Archana Singh-ManouxDepartment of Epidemiology and Public Health, University College London, London, United Kingdom.
Juha AuvinenCenter for Life Course Health Research, University of Oulu, Oulu, Finland.
Nina Hutri-KähönenDepartment of Pediatrics, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Mika KähönenDepartment of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Lena KilanderDepartment of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
Katri RäikkönenDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
Håkan MelhusDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Erik IngelssonDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Idris GuessousUnit of Population Epidemiology, Division of Primary Care Medicine, Department of Community Medicine, Primary Care and Emergency Medicine, Geneva University Hospitals, Geneva, Switzerland.
Katja E PetrovicDivision of General Neurology, Department of Neurology, General Hospital and Medical University of Graz, Graz, Austria.
Helena SchmidtResearch Unit for Genetic Epidemiology, Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, Graz, Austria.
Reinhold SchmidtDepartment of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria.
Peter VollenweiderDepartment of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Lars LindDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Johan G ErikssonDepartment of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Karl MichaëlssonDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Olli T RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Sara HäggDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Karl-Heinz HerzigResearch Unit of Biomedicine, University of Oulu, Oulu, Finland.
Marjo-Riitta JärvelinCenter for Life Course Health Research, University of Oulu, Oulu, Finland.
Juha VeijolaMedical Research Center (MRC) and Oulu University Hospital, Oulu, Finland.
Mika KivimakiDepartment of Epidemiology and Public Health, University College London, London, United Kingdom.ORCID 0000-0002-4699-5627
Rolf JordeDivision of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Meena KumariInstitute for Social and Economic Research (ISER), University of Essex, Colchester, United Kingdom.
Chris PowerPopulation, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom.
David J LlewellynUniversity of Exeter Medical School, Exeter, United Kingdom.
Elina HyppönenPopulation, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, United Kingdom. elina.hypponen@unisa.edu.au.
Funding
Causal associations of circulating biomarkers with cardiovascular diseaseR01HL135313 · NHLBI · STANFORD UNIVERSITY · PI INGELSSON, ERIK · 2017 to 2019
$1.6MBritish Heart Foundation PG/09/023/26806Department of Health PHCS/C4/4/016Medical Research Council G0601653Medical Research Council G1001799Medical Research Council MC_UU_12019/2Medical Research Council MR/N01104X/1Medical Research Council MR/N01104X/2NHLBI NIH HHS R01 HL135313
Abstract
The causal nature of the association between hypovitaminosis D and poor cognitive function in mid- to later-life is uncertain. Using a Mendelian randomisation(MR) approach, we examined the causal relationship between 25(OH)D and cognitive function. Data came from 172,349 participants from 17 cohorts. DHCR7(rs12785878), CYP2R1 rs12794714) and their combined synthesis score were chosen to proxy 25(OH)D. Cognitive tests were standardised into global and memory scores. Analyses were stratified by 25(OH)D tertiles, sex and age. Random effects meta-analyses assessed associations between 25(OH)D and cognitive function. Associations of serum 25(OH)D with global and memory-related cognitive function were non-linear (lower cognitive scores for both low and high 25(OH)D, p
Indexed as
AgedCognitionCohort StudiesFemaleHumansMaleMendelian Randomization AnalysisMiddle AgedPhenotypePolymorphism, Single NucleotideVitamin DVitamins25-hydroxyvitamin DVitamin DVitamins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.