ArticleScientific reports2017
Lure-and-Kill Yeast Interfering RNA Larvicides Targeting Neural Genes in the Human Disease Vector Mosquito Aedes aegypti.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 58 citations in OpenAlex.
- Mosquito-based malaria control through genetic, microbial and immunological innovations.Nature reviews. Microbiology · 2026Review
- Targeting the Highly Invasive Malaria Vector Anopheles stephensi using Yeast RNAi Pesticides.Research square · 2026Article
- Ecotoxicological and behavioural responses of aquatic model organisms to the MosChito raft bioinsecticide delivery system.Scientific reports · 2026Article
- Advances in male sex separation for the support of mosquito control programs.Frontiers in insect science · 2026Review
- Development of an eco-friendly RNAi yeast attractive targeted sugar bait that silences the shaker gene in spotted-wing drosophila, Drosophila suzukii.Pest management science · 2026Article
- Review
- The quest for the best target genes for RNAi-mediated pest control.Insect molecular biology · 2025Review
- Yeast Oral Delivery of DAF16 shRNAs Results in Effective Gene Silencing inCurrent issues in molecular biology · 2025Article
- Behavioral responses of Phlebotomus papatasi (Diptera: Psychodidae) to host-derived semiochemicals.Journal of medical entomology · 2025Article
- Article
- Development of a controlled-release mosquito RNAi yeast larvicide suitable for the sustained control of large water storage containers.Scientific reports · 2024Article
- Challenges of Robust RNAi-Mediated Gene Silencing inInternational journal of molecular sciences · 2024Article
- Characterization of a novel RNAi yeast insecticide that silences mosquito 5-HT1 receptor genes.Scientific reports · 2023Article
- RNA Vaccines: Yeast as a Novel Antigen Vehicle.Vaccines · 2023Review
- Maximizing the Potential of Attractive Targeted Sugar Baits (ATSBs) for Integrated Vector Management.Insects · 2023Review
- MosChito rafts as a promising biocontrol tool against larvae of the common house mosquito, Culex pipiens.PloS one · 2023Article
- Oral RNAi for Gene Silencing in Mosquitoes: From the Bench to the Field.Cold Spring Harbor protocols · 2022Article
- Field trials reveal the complexities of deploying and evaluating the impacts of yeast-baited ovitraps on Aedes mosquito densities in Trinidad, West Indies.Scientific reports · 2022Article
- A Conserved Female-Specific Requirement for thePathogens (Basel, Switzerland) · 2022Article
- RNAi-based pest control: Production, application and the fate of dsRNA.Frontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
New mosquito control strategies are vitally needed to address established arthropod-borne infectious diseases such as dengue and yellow fever and emerging diseases such as Zika and chikungunya, all of which are transmitted by the disease vector mosquito Aedes aegypti. In this investigation, Saccharomyces cerevisiae (baker's yeast) was engineered to produce short hairpin RNAs (shRNAs) corresponding to the Aedes aegypti orthologs of fasciculation and elongation protein zeta 2 (fez2) and leukocyte receptor cluster (lrc) member, two genes identified in a recent screen for A. aegypti larval lethal genes. Feeding A. aegypti with the engineered yeasts resulted in silenced target gene expression, disrupted neural development, and highly significant larval mortality. Larvicidal activities were retained following heat inactivation and drying of the yeast into tabular formulations that induced >95% mortality and were found to attract adult females to oviposit. These ready-to-use inactivated yeast interfering RNA tablets may one day facilitate the seamless integration of this new class of lure-and-kill species-specific biorational mosquito larvicides into integrated mosquito control programs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.