ArticleNature communications2017
Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ.
Open access · goldAbstract read
In one paragraph
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
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Who cites it
21 citing papers in PubMed, 58 citations in OpenAlex.
- NovelGenes & diseases · 2026Article
- A novel pan-PI3K inhibitor KTC1101 synergizes with anti-PD-1 therapy by targeting tumor suppression and immune activation.Molecular cancer · 2024Article
- Hypothermic machine perfusion reduces donation after circulatory death liver ischemia-reperfusion injury through the SERPINA3-mediated PI3Kδ/Akt pathway.Human cell · 2024Article
- Inhibition of phosphoinositide‑3 kinases γ/δ ameliorates pulmonary granuloma by rescuing Treg function in a sarcoidosis model.Experimental and therapeutic medicine · 2023Article
- Dual inhibition of phosphoinositide 3-kinases delta and gamma reduces chronic B cell activation and autoantibody production in a mouse model of lupus.Frontiers in immunology · 2023Article
- Therapeutic targeting of regulatory T cells in cancer.Trends in cancer · 2022Review
- The therapeutic implications of immunosuppressive tumor aerobic glycolysis.Cellular & molecular immunology · 2022Review
- Cancer cell targeting by CAR-T cells: A matter of stemness.Frontiers in molecular medicine · 2022Review
- A Review of Phosphocreatine 3 Kinase δ Subtype (PI3Kδ) and Its Inhibitors in Malignancy.Medical science monitor : international medical journal of experimental and clinical research · 2021Review
- ACTH treatment promotes murine cardiac allograft acceptance.JCI insight · 2021Article
- Hyperactive PI3Kδ predisposes naive T cells to activation via aerobic glycolysis programs.Cellular & molecular immunology · 2021Article
- PI3K in T Cell Adhesion and Trafficking.Frontiers in immunology · 2021Review
- Integrin signaling gene alterations and outcomes of cancer patients receiving immune checkpoint inhibitors.American journal of translational research · 2021Article
- Strategies to Overcome Failures in T-Cell Immunotherapies by Targeting PI3K-δ and -γ.Frontiers in immunology · 2021Review
- Article
- Loss of Phosphatidylinositol 3-Kinase Activity in Regulatory T Cells Leads to Neuronal Inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Identification of differentially expressed genes and biological pathways in para-carcinoma tissues of HCC with different metastatic potentials.Oncology letters · 2020Article
- Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology.Nature communications · 2019Article
- Targeting PI3Kδ function for amelioration of murine chronic graft-versus-host disease.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Article
- Dual blockade of the PI3K/Akt/mTOR pathway inhibits posttransplant Epstein-Barr virus B cell lymphomas and promotes allograft survival.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Mayuko UeharaTransplantation Research Center, Renal Division, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA.
Martina M McGrathTransplantation Research Center, Renal Division, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA.
Shunsuke OhoriTransplantation Research Center, Renal Division, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA.
Zhabiz SolhjouTransplantation Research Center, Renal Division, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA.
Naima BanouniTransplantation Research Center, Renal Division, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA.
Sujit RoutrayTransplantation Research Center, Renal Division, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA.
Catherine EvansInfinity Pharmaceuticals, Inc 784 Memorial Drive, Cambridge, MA, 02139, USA.
Jonathan P DiNittoInfinity Pharmaceuticals, Inc 784 Memorial Drive, Cambridge, MA, 02139, USA.
Abdallah ElkhalDivision of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Laurence A TurkaCenter for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Massachusetts Massachusetts General Hospital-East Charlestown Navy Yard Building 149, 13th Street, Charlestown, MA, 02129-2020, USA.
Terry B StromThe Transplant Institute, Beth Israel Deaconess Medical Center/Harvard Medical School, 330 Brookline Avenue, E/CLS Room 607, Boston, MA, 02215, USA.
Stefan G TulliusDivision of Transplant Surgery and Transplant Surgery Research Laboratory, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
David G WinklerInfinity Pharmaceuticals, Inc 784 Memorial Drive, Cambridge, MA, 02139, USA.
Jamil AzziTransplantation Research Center, Renal Division, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA.
Reza AbdiTransplantation Research Center, Renal Division, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA. rabdi@rics.bwh.harvard.edu.
Harvard University · USBrigham and Women's Hospital · USInfinity Pharmaceuticals (United States) · US
Funding
Transgenic/KnockoutP01AI056299 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SHARPE, ARLENE H. · 2003 to 2023
$42.5MProtection of organ transplant from ischemia reperfusion injuriesR01AI126596 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI ABDI, REZA · 2016 to 2020
$2.6MIschemia-reperfusion injury in transplantation: novel cytoprotection strategiesR01AI091930 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI ABDI, REZA · 2011 to 2015
$2.1MThe novel role of the PI3Kγ and δ pathways in alloimmunityR56AI123270 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI ABDI, REZA · 2016 to 2016
$404kNIAID NIH HHS P01 AI056299NIAID NIH HHS R01 AI091930NIAID NIH HHS R01 AI126596NIAID NIH HHS R56 AI123270
Abstract
Phosphatidylinositol-3-kinases (PI3K) γ and δ are preferentially enriched in leukocytes, and defects in these signaling pathways have been shown to impair T cell activation. The effects of PI3Kγ and PI3Kδ on alloimmunity remain underexplored. Here, we show that both PI3Kγ
Indexed as
Heart TransplantationSkin TransplantationAbataceptAnimalsClass Ib Phosphatidylinositol 3-KinaseClass I Phosphatidylinositol 3-KinasesGene Knockdown TechniquesGraft RejectionGraft SurvivalImmunosuppressive AgentsLymphocyte ActivationMiceMice, KnockoutModels, AnimalMutationPhosphatidylinositol 3-KinasesAbataceptClass Ib Phosphatidylinositol 3-KinaseClass I Phosphatidylinositol 3-KinasesImmunosuppressive AgentsPhosphatidylinositol 3-KinasesPik3cd protein, mousePik3cg protein, mouse
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.