ArticleCancer research2017
Blocking Myristoylation of Src Inhibits Its Kinase Activity and Suppresses Prostate Cancer Progression.
Abstract read
In one paragraph
Article in Cancer research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 86 citations in OpenAlex.
- Randomized Phase II Trial of Abiraterone Alone or With Dasatinib in Men With Metastatic Castration-resistant Prostate Cancer (mCRPC).Clinical genitourinary cancer · 2019Trial
- N-myristoyltransferase 1, a key gene for protein N-myristoylation, is dispensable for fertility in male mice.The Journal of reproduction and development · 2026Article
- N-Myristoyltransferase 2 Is Regulated by Polyphosphate-Driven Lysine Interactions.Biomolecules · 2026Article
- Protein lipidation in cardiovascular homeostasis, development, and disease.Clinical science (London, England : 1979) · 2026Review
- Crosstalk between protein lipidation and ubiquitination in tumor biology.Apoptosis : an international journal on programmed cell death · 2026Review
- Sustained monocyte activation by persistent challenges with either oxLDL or free cholesterol and underlying mechanisms.ImmunoHorizons · 2026Article
- Processes and therapeutic perspectives of acylation modifications of lysine and cysteine in tumors.Cell communication and signaling : CCS · 2026Review
- Extracellular vesicle-mediated delivery of CRISPR machinery silences androgen receptor in castration-resistant prostate cancer cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- CUL4A-DDB1-DCAF10 is an N-recognin for N-terminally acetylated Src kinases.Nature communications · 2026Article
- Post-translational modifications at the crossroads of cancer metabolism and immune regulation: therapeutic opportunities and challenges.International journal of surgery (London, England) · 2026Review
- SLC7A11-AS1 contributes to prolonged activation of activin A/Smad signaling by suppressing PPM1A myristoylation in pancreatic cancer.British journal of cancer · 2025Article
- Targeting Src tyrosine kinase to enhance radioiodide uptake in breast cancer.Endocrine-related cancer · 2025Article
- Extracellular Vesicles in the Crosstalk of Autophagy and Apoptosis: A Role for Lipid Rafts.Cells · 2025Review
- Protein lipidation in the tumor microenvironment: enzymology, signaling pathways, and therapeutics.Molecular cancer · 2025Review
- Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity.Nature cancer · 2025Article
- Exploring Subsite Selectivity withinJournal of medicinal chemistry · 2024Article
- Multiomics analysis identifies oxidative phosphorylation as a cancer vulnerability arising from myristoylation inhibition.Journal of translational medicine · 2024Article
- Protein lipidation in health and disease: molecular basis, physiological function and pathological implication.Signal transduction and targeted therapy · 2024Review
- Inhibition of N-myristoyltransferase activity promotes androgen receptor degradation in prostate cancer.The Prostate · 2024Article
- The role of N-myristoyltransferase 1 in tumour development.Annals of medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 1 institution in 1 country.
Sungjin KimDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia Athens, Athens, Georgia.
Omar Awad AlsaidanDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia Athens, Athens, Georgia.
Octavia GoodwinDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia Athens, Athens, Georgia.
Qianjin LiDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia Athens, Athens, Georgia.
Essilvo SulejmaniDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia Athens, Athens, Georgia.
Zhen HanDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia Athens, Athens, Georgia.
Aiping BaiDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.
Thomas AlbersDepartment of Chemistry and Physics, Augusta University, Augusta, Georgia.
Zanna BeharryDepartment of Chemistry and Physics, Florida Gulf Coast University, Fort Myers, Florida.
Y George ZhengDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia Athens, Athens, Georgia.
James S NorrisDepartment of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina.
Zdzislaw M SzulcDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.
Alicja BielawskaDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.
Iryna LebedyevaDepartment of Chemistry and Physics, Augusta University, Augusta, Georgia.
Scott D PeganDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia Athens, Athens, Georgia.
Houjian CaiDepartment of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia Athens, Athens, Georgia. caihj@uga.edu.
Medical University of South Carolina · US
Funding
Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND N. DUBOIS · 2009 to 2026
$42.7MTargeting myristoylation of Src family kinases for inhibition of prostate tumorigenesisR01CA172495 · NCI · UNIVERSITY OF GEORGIA · PI CAI, HOUJIAN · 2013 to 2017
$1.7MChemical Approaches to Protein Arginine MethylationR01GM086717 · NIGMS · UNIVERSITY OF GEORGIA · PI ZHENG, Y. GEORGE · 2010 to 2014
$1.2MNCI NIH HHS P30 CA138313NCI NIH HHS R01 CA172495NIGMS NIH HHS R01 GM086717
Abstract
Protein
Indexed as
AcyltransferasesAmino Acid SubstitutionAnimalsCells, CulturedDisease ProgressionEnzyme InhibitorsHEK293 CellsHumansMaleMiceMice, Inbred C57BLMice, SCIDMutation, MissenseMyristic AcidPhosphorylationPhosphotransferasesAcyltransferasesEnzyme Inhibitorsglycylpeptide N-tetradecanoyltransferaseMyristic AcidPhosphotransferasesProto-Oncogene Proteins pp60(c-src)Tumor Suppressor Proteins
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.