ArticleEndocrine connections2017
Can growth hormone treatment improve growth in children with severe growth failure due to anorexia nervosa? A preliminary pilot study.
Article in Endocrine connections, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Therapeutic approaches for endocrine dysregulation in anorexia nervosa in adolescents.Frontiers in pediatrics · 2026Review
- Adoptive Transfer of LeprInternational journal of molecular sciences · 2025Article
- Early-onset anorexia nervosa: a scoping review and management guidelines.Journal of eating disorders · 2024Article
- Cognition, motor symptoms, and glycolipid metabolism in Parkinson's disease with depressive symptoms.Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- The Effects of Nutrition on Linear Growth.Nutrients · 2022Review
- Potential applications for rhIGF-I: Bone disease and IGFI.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2020Review
- Refeeding in anorexia nervosa.European journal of pediatrics · 2019Article
- Medication in AN: A Multidisciplinary Overview of Meta-Analyses and Systematic Reviews.Journal of clinical medicine · 2019Review
- MECHANISMS IN ENDOCRINOLOGY: Anorexia nervosa and endocrinology: a clinical update.European journal of endocrinology · 2019Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsGrowth failure is a difficult but key aspect of care in children with anorexia nervosa (AN). The effects of hGH therapy have not been studied. The aim was to investigate the effect of hGH treatment on height velocity (HV) in children with AN.
methodsWe carried out a retrospective observational study. Ten girls diagnosed with AN at 10.0 ± 1.9 years, with prolonged severe growth failure (HV < 2.5 cm/year for at least 18 months) at the age of 13.3 ± 1.1 years and delayed puberty after nutritional rehabilitation, were treated with hGH (0.040 mg/kg/day) from a bone age of 10.9 ± 1.7 years until they reached adult height. Height and HV were measured before treatment and at 12-month intervals during treatment.
resultsMean body mass index SDS remained unchanged, but HV increased significantly, from a median of 1.0 (0.7-2.1) to 7.1 (6.0-9.5) cm/year after one year (
conclusionsThis proof-of-concept study shows that hGH treatment is associated with significant improvements in linear growth in adolescents with AN and severe growth failure. A randomized placebo-controlled trial is required to determine the ultimate impact of GH treatment in patients with this severe, rare condition.
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