Evidence map›Paper›PMID 29038285›Full record

Trial reportJournal of the American Society of Nephrology : JASN2018

Metabolic Effects of Diet and Exercise in Patients with Moderate to Severe CKD: A Randomized Clinical Trial.

T Alp Ikizler, Cassianne Robinson-Cohen, Charles Ellis, Samuel A E Headley, Katherine Tuttle, Richard J Wood, Elizabeth Elspeth Evans, Charles M Milch, Kelsey Anne Moody, Michael Germain and 4 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Society of Nephrology : JASN, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 16 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 16 syntheses or guidelines pooled it, 144 citations in OpenAlex.

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  17. Effect of Long-term Exercise Training on Physical Performance and Cardiorespiratory Function in Adults With CKD: A Randomized Controlled Trial.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2023
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  20. Muscle mass and plasma myostatin after exercise training: a substudy of Renal Exercise (RENEXC)-a randomized controlled trial.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021
    Trial

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 3 countries.

T Alp IkizlerDivision of Nephrology, Department of Medicine.
Cassianne Robinson-CohenDivision of Nephrology, Department of Medicine.
Charles EllisDivision of Nephrology, Department of Medicine.
Samuel A E HeadleyDepartment of Exercise Science and Sport Studies, Springfield College, Springfield, Massachusetts.
Katherine TuttleKidney Research Institute and.
Richard J WoodDepartment of Exercise Science and Sport Studies, Springfield College, Springfield, Massachusetts.
Elizabeth Elspeth EvansDepartment of Exercise Science and Sport Studies, Springfield College, Springfield, Massachusetts.
Charles M MilchDepartment of Exercise Science and Sport Studies, Springfield College, Springfield, Massachusetts.
Kelsey Anne MoodyDepartment of Exercise Science and Sport Studies, Springfield College, Springfield, Massachusetts.
Michael GermainUniversity of Massachusetts School of Medicine, Baystate Medical Center, Springfield, Massachusetts; and.
Chutatip LimkunakulDepartment of Medicine, Panyananthaphikkhu Chonprathan Medical Center, Srinakharinwirot University, Pakkret, Thailand.
Aihua BianDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
Thomas G StewartDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
Jonathan HimmelfarbKidney Research Institute and.
Springfield College · USVanderbilt University Medical Center · USBaystate Medical Center · USProvidence Health & Services · USSrinakharinwirot University · THUniversity of Washington · US

Funding

Transform Dissemination and Implementation Science in CTSA ProgramsUL1TR002319 · NCATS · UNIVERSITY OF WASHINGTON · PI John K. Amory · 2017 to 2026
$100.0M
Institute of Translational Health SciencesUL1TR000423 · NCATS · UNIVERSITY OF WASHINGTON · PI DISIS, MARY L. · 2012 to 2016
$49.4M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
PILOT STUDY--CLINICAL NUTRITION RESEARCHP30DK035816 · NIDDK · UNIVERSITY OF WASHINGTON · PI Ellen A Schur · 1986 to 2026
$30.4M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3M
Structural Biology Facility CoreP30ES000267 · NIEHS · VANDERBILT UNIVERSITY · PI GUENGERICH, F PETER · 1985 to 2014
$20.3M
Oxidative Stress in Chronic Kidney DiseaseR01HL070938 · NHLBI · UNIVERSITY OF WASHINGTON · PI HIMMELFARB, JONATHAN, IKIZLER, TALAT ALP · 2003 to 2012
$3.2M
Nutrition and Metabolism in Dialysis PatientsK24DK062849 · NIDDK · VANDERBILT UNIVERSITY · PI IKIZLER, TALAT ALP · 2003 to 2012
$1.6M
NCATS NIH HHS UL1 TR000423NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002319NHLBI NIH HHS R01 HL070938NIDDK NIH HHS K24 DK062849NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK035816NIEHS NIH HHS P30 ES000267
6 · The paper itself

Abstract

CKD is steadily increasing along with obesity worldwide. Furthermore, obesity is a proinflammatory risk factor for progression of CKD and cardiovascular disease. We tested the hypothesis that implementation of caloric restriction and aerobic exercise is feasible and can improve the proinflammatory metabolic milieu in patients with moderate to severe CKD through a pilot, randomized, 2×2 factorial design trial. Of 122 participants consented, 111 were randomized to receive caloric restriction and aerobic exercise, caloric restriction alone, aerobic exercise alone, or usual care. Of those randomized, 42% were women, 25% were diabetic, and 91% were hypertensive; 104 started intervention, and 92 completed the 4-month study. Primary outcomes were a change from baseline in absolute fat mass, body weight, plasma F

Indexed as

Caloric RestrictionAdiposityAgedAlbuminuriaBody WeightCreatinineExerciseF2-IsoprostanesFemaleGlomerular Filtration RateHumansInterleukin-6MaleMiddle AgedOxidative StressOxygen ConsumptionCreatinineF2-IsoprostanesIL6 protein, humanInterleukin-6Chronic inflammationchronic kidney diseasedietexercisemetabolismoxidative stress

Identifiers

PMID29038285
PMCPMC5748901
OpenAlexW2765327091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.