Evidence map›Paper›PMID 29038284›Full record

ArticleAntimicrobial agents and chemotherapy2018

Evaluation of the Microbiological Efficacy of a Single 2-Gram Dose of Extended-Release Azithromycin by Population Pharmacokinetics and Simulation in Japanese Patients with Gonococcal Urethritis.

Midori Soda, Shin Ito, Naoki Matsumaru, Sakiko Nakamura, Izumi Nagase, Hikari Takahashi, Yuta Ohno, Mitsuru Yasuda, Miho Yamamoto, Katsura Tsukamoto and 3 more

Open access · bronzeAbstract readEvaluation Study
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Molecular epidemiology and pharmacokinetic-pharmacodynamic analysis of Neisseria gonorrhoeae strains in Northern Spain.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Rationale for a Neisseria gonorrhoeae Susceptible-only Interpretive Breakpoint for Azithromycin.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  8. Trends and Risk Factors for Antimicrobial-ResistantAntimicrobial agents and chemotherapy · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Midori SodaLaboratory of Pharmaceutics, Department of Biomedical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan.
Shin ItoDepartment of Urology, Gifu University Graduate School of Medicine, Gifu, Japan.
Naoki MatsumaruGlobal Regulatory Science, Gifu Pharmaceutical University, Gifu, Japan.
Sakiko NakamuraLaboratory of Pharmaceutics, Department of Biomedical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan.
Izumi NagaseLaboratory of Pharmaceutics, Department of Biomedical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan.
Hikari TakahashiLaboratory of Pharmaceutics, Department of Biomedical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan.
Yuta OhnoDepartment of Pharmacy, Gifu University Hospital, Gifu, Japan.
Mitsuru YasudaDepartment of Urology, Gifu University Graduate School of Medicine, Gifu, Japan.
Miho YamamotoGlobal Regulatory Science, Gifu Pharmaceutical University, Gifu, Japan.
Katsura TsukamotoGlobal Regulatory Science, Gifu Pharmaceutical University, Gifu, Japan.
Yoshinori ItohDepartment of Pharmacy, Gifu University Hospital, Gifu, Japan.
Takashi DeguchiDepartment of Urology, Gifu University Graduate School of Medicine, Gifu, Japan.
Kiyoyuki KitaichiLaboratory of Pharmaceutics, Department of Biomedical Pharmaceutics, Gifu Pharmaceutical University, Gifu, Japan kitaichi@gifu-pu.ac.jp.
Gifu Pharmaceutical University · JPGifu University · JPGifu University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to analyze the relationship between the pharmacokinetic (PK)/pharmacodynamic (PD) parameters of a single 2-g dose of extended-release formulation of azithromycin (AZM-SR) and its microbiological efficacy against gonococcal urethritis. Fifty male patients with gonococcal urethritis were enrolled in this study. In 36 patients, the plasma AZM concentrations were measured using liquid chromatography-tandem mass spectrometry, the AZM MIC values for the

Indexed as

AdultAnti-Bacterial AgentsAzithromycinDelayed-Action PreparationsGonorrheaHumansJapanMaleMicrobial Sensitivity TestsMiddle AgedNeisseria gonorrhoeaeTreatment OutcomeUrethritisYoung AdultAnti-Bacterial AgentsAzithromycinDelayed-Action Preparationsazithromycingonococcal urethritisMonte Carlo simulationNeisseria gonorrhoeaePK/PD

Identifiers

PMID29038284
PMCPMC5740364
OpenAlexW2766440266

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.