Evidence map›Paper›PMID 29038270›Full record

ArticleAntimicrobial agents and chemotherapy2018

Activity of Meropenem-Vaborbactam against Carbapenem-Resistant Enterobacteriaceae in a Murine Model of Pyelonephritis.

William J Weiss, Mark E Pulse, Phung Nguyen, Kelly Peterson, Jessica Silva, Jerry W Simecka, David Valtierra, Mojgan Sabet, David C Griffith

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. New β-Lactam-β-Lactamase Inhibitor Combinations.Clinical microbiology reviews · 2020
    Review
  6. Review
  7. Review of Ceftazidime-Avibactam, Meropenem-Vaborbactam, and Imipenem/Cilastatin-Relebactam to TargetThe Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2020
    Review
  8. Review
  9. Antimicrobial agents and chemotherapy · 2019
    Article
  10. Article
  11. Meropenem-vaborbactam: a carbapenem and beta-lactamase inhibitor with activity against carbapenem-resistant Enterobacteriaceae.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2018
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

William J WeissPre-Clinical Services at UNT Health Science Center, Fort Worth, Texas, USA william.weiss@unthsc.edu.
Mark E PulsePre-Clinical Services at UNT Health Science Center, Fort Worth, Texas, USA.
Phung NguyenPre-Clinical Services at UNT Health Science Center, Fort Worth, Texas, USA.
Kelly PetersonPre-Clinical Services at UNT Health Science Center, Fort Worth, Texas, USA.
Jessica SilvaPre-Clinical Services at UNT Health Science Center, Fort Worth, Texas, USA.
Jerry W SimeckaPre-Clinical Services at UNT Health Science Center, Fort Worth, Texas, USA.
David ValtierraPre-Clinical Services at UNT Health Science Center, Fort Worth, Texas, USA.
Mojgan SabetThe Medicines Company, San Diego, California, USA.ORCID 0000-0002-5417-0262
David C GriffithThe Medicines Company, San Diego, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The recently approved combination of meropenem and vaborbactam (Vabomere) is highly active against Gram-negative pathogens, especially

Indexed as

AnimalsAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamase Inhibitorsbeta-LactamasesBoronic AcidsCarbapenem-Resistant EnterobacteriaceaeDisease Models, AnimalDrug CombinationsEscherichia coliHumansKlebsiella pneumoniaeMeropenemMiceMicrobial Sensitivity TestsPyelonephritisAnti-Bacterial AgentsBacterial Proteinsbeta-Lactamase Inhibitorsbeta-LactamasesBoronic AcidscarbapenemaseDrug CombinationsMeropenemvaborbactamKlebsiella pneumoniae carbapenemaseKPCmeropenempyelonephritisvaborbactam

Identifiers

PMID29038270
PMCPMC5740365

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.