ArticleJournal of immunology (Baltimore, Md. : 1950)2017
Lipopolysaccharide Potentiates Insulin-Driven Hypoglycemic Shock.
Article in Journal of immunology (Baltimore, Md. : 1950), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- NADeLife · 2024Article
- Association Between Hypoglycemia and the Occurrence of Early Onset Sepsis in Premature Infants.Journal of the Pediatric Infectious Diseases Society · 2023Article
- Severe hyperglycemia and insulin resistance in patients with SARS-CoV-2 infection: a report of two cases.Clinical diabetes and endocrinology · 2021Article
- Gingival-Derived Mesenchymal Stem Cells Protect Against Sepsis and Its Complications.Infection and drug resistance · 2021Article
- Gut microbiota impairs insulin clearance in obese mice.Molecular metabolism · 2020Article
- An overview of the non-canonical inflammasome.Molecular aspects of medicine · 2020Review
- Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium.Cell reports · 2020Article
- Insulin Reduces Inflammation by Regulating the Activation of the NLRP3 Inflammasome.Frontiers in immunology · 2020Article
- Accuracy of the point-of-care glucose meter for use in calves.The Journal of veterinary medical science · 2019Article
- Central metabolic interactions of immune cells and microbes: prospects for defeating infections.EMBO reports · 2019Review
- The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages.Nature communications · 2018Article
- Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis.Journal of inflammation (London, England) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Critically ill patients typically present with hyperglycemia. Treatment with conventional insulin therapy (targeting 144-180 mg/dl) improves patient survival; however, intensive insulin therapy (IIT) targeting normal blood glucose levels (81-108 mg/dl) increases the incidence of moderate and severe hypoglycemia, and increases mortality. Septic patients are especially prone to IIT-induced hypoglycemia, but the mechanism remains unknown. Here, we show that codelivery of insulin with otherwise sublethal doses of LPS induced hypoglycemic shock in mice within 1-2 h. LPS impaired clearance of insulin, which amplified insulin receptor signaling. These effects were mediated by caspase-11, TLR4, and complement, each of which trigger eicosanoid production that potentiates insulin signaling. Finally, in an animal model of sepsis, we observed that
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.