Evidence map›Paper›PMID 29038238›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Delayed Maturation of Fast-Spiking Interneurons Is Rectified by Activation of the TrkB Receptor in the Mouse Model of Fragile X Syndrome.

Toshihiro Nomura, Timothy F Musial, John J Marshall, Yiwen Zhu, Christine L Remmers, Jian Xu, Daniel A Nicholson, Anis Contractor

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 64 citations in OpenAlex.

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  6. More Than a Small Brain: The Importance of Studying Neural Function during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
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  10. In Vitro Patch-Clamp.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Toshihiro NomuraDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Timothy F MusialDepartment of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, and.ORCID 0000-0003-0533-7967
John J MarshallDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.ORCID 0000-0002-6481-8413
Yiwen ZhuDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Christine L RemmersDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Jian XuDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
Daniel A NicholsonDepartment of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, and.
Anis ContractorDepartment of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, a-contractor@northwestern.edu.ORCID 0000-0002-5131-2536
Northwestern University · USRush University Medical Center · US

Funding

The role of glutamate receptors in compulsive and perseverative behaviorR01MH099114 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CONTRACTOR, ANIS · 2012 to 2022
$4.5M
Proteomic reconstructive microscopy of healthy and diseased dendritesR01AG047073 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI NICHOLSON, DANIEL A · 2013 to 2016
$1.3M
Computational neurobiology of hippocampal dendritesK02AG050767 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI NICHOLSON, DANIEL A · 2015 to 2019
$603k
Chloride homeostasis and GABA maturation in fragile X syndromeR21MH104808 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CONTRACTOR, ANIS · 2015 to 2016
$425k
NIA NIH HHS K02 AG050767NIA NIH HHS R01 AG047073NIMH NIH HHS R01 MH099114NIMH NIH HHS R21 MH104808
6 · The paper itself

Abstract

Fragile X syndrome (FXS) is a neurodevelopmental disorder that is a leading cause of inherited intellectual disability, and the most common known cause of autism spectrum disorder. FXS is broadly characterized by sensory hypersensitivity and several developmental alterations in synaptic and circuit function have been uncovered in the sensory cortex of the mouse model of FXS (

Indexed as

Excitatory Postsynaptic PotentialsAnimalsFemaleFragile X Messenger Ribonucleoprotein 1Fragile X SyndromeGABAergic NeuronsInterneuronsMiceMice, Inbred C57BLReceptor, trkBSomatosensory CortexFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1Receptor, trkBcritical periodfast-spiking interneuronfragile X syndromesomatosensory cortexsynapseTrkB

Identifiers

PMID29038238
PMCPMC5700416
OpenAlexW2766135107

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.