Evidence map›Paper›PMID 29038237›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

The Gain-of-Function Integrin β3 Pro33 Variant Alters the Serotonin System in the Mouse Brain.

Michael R Dohn, Christopher G Kooker, Lisa Bastarache, Tammy Jessen, Capria Rinaldi, Seth Varney, Matthew D Mazalouskas, Hope Pan, Kendra H Oliver, Digna R Velez Edwards and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Modulation of the Mechanosensory Matrisome by Serotonergic Signaling.Results and problems in cell differentiation · 2026
    Review
  3. Review
  4. Review
  5. CRISPR-mediated activation of autism geneMolecular therapy. Nucleic acids · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Genetic deletion ofJournal of psychopharmacology (Oxford, England) · 2020
    Article
  12. Article
  13. Observational
  14. Blood platelet research in autism spectrum disorders: In search of biomarkers.Research and practice in thrombosis and haemostasis · 2019
    Review
  15. Article
  16. Article
  17. p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 7 countries.

Michael R DohnDepartments of Pharmacology.
Christopher G KookerDepartments of Pharmacology.ORCID 0000-0001-6826-1088
Lisa BastaracheBiomedical Informatics and Medicine.
Tammy JessenDepartments of Pharmacology.ORCID 0000-0002-7279-057X
Capria RinaldiDepartments of Pharmacology.
Seth VarneyDepartments of Pharmacology.
Matthew D MazalouskasDepartments of Pharmacology.
Hope PanDepartments of Pharmacology.
Kendra H OliverDepartments of Pharmacology.ORCID 0000-0003-3142-5186
Digna R Velez EdwardsObstetrics and Gynecology, and.
James S SutcliffePsychiatry and Molecular Physiology & Biophysics, and.ORCID 0000-0001-5200-6007
Joshua C DennyBiomedical Informatics and Medicine.ORCID 0000-0002-3049-7332
Ana M D CarneiroDepartments of Pharmacology, ana.carneiro@vanderbilt.edu.ORCID 0000-0002-1204-9202
Institute of Pharmacology · CZVanderbilt University · USTranslational Research Informatics Center (Japan) · JP

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3M
Shop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6M
Vanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9M
Program in NeurogenomicsT32MH065215 · NIMH · VANDERBILT UNIVERSITY · PI ROGER J COLBRAN · 2002 to 2026
$6.4M
From GWAS to PheWAS: Scanning the EMR Phenome for Gene-disease AssociationsR01LM010685 · NLM · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BASTARACHE, LISA · 2011 to 2022
$6.3M
Vanderbilt Mouse Metabolic Phenotyping CenterU2CDK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2016 to 2021
$6.3M
Discovering Biology for Neuropsychiatric Diseases Through Omics Studies on ComorbiditiesR01MH113362 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COX, NANCY J, KNAPIK, ELA W · 2017 to 2021
$3.9M
Unraveling the Genetic Etiology of AutismR01NS049261 · NINDS · VANDERBILT UNIVERSITY · PI SUTCLIFFE, JAMES S · 2006 to 2010
$2.5M
Regulation of the Serotonin Transporter Function by Integrins in the Mouse BrainR01MH090256 · NIMH · VANDERBILT UNIVERSITY · PI CARNEIRO, ANA MARIN DIAS · 2011 to 2015
$1.9M
NCI NIH HHS P30 CA068485NEI NIH HHS P30 EY008126NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS U24 DK059637NIDDK NIH HHS U2C DK059637NIMH NIH HHS R01 MH090256NIMH NIH HHS R01 MH113362NIMH NIH HHS T32 MH065215NINDS NIH HHS R01 NS049261NLM NIH HHS R01 LM010685
6 · The paper itself

Abstract

Engagement of integrins by the extracellular matrix initiates signaling cascades that drive a variety of cellular functions, including neuronal migration and axonal pathfinding in the brain. Multiple lines of evidence link the

Indexed as

AnimalsBrainFemaleGain of Function MutationGene Knock-In TechniquesGenetic VariationHumansIntegrin beta3MaleMiceMice, Inbred C57BLMice, TransgenicProlineProtein BindingSerotoninSerotonin Plasma Membrane Transport ProteinsIntegrin beta3ProlineSerotoninSerotonin Plasma Membrane Transport ProteinsFAKfocal adhesionintegrin beta3ITGB3serotoninSERT

Identifiers

PMID29038237
PMCPMC5688530
OpenAlexW2766953506

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.