Evidence map›Paper›PMID 29038206›Full record

ArticleCirculation2017

Closing the Genotype-Phenotype Loop for Precision Medicine.

Calum A MacRae, Christine E Seidman

Abstract readEditorialComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. From Stripes to a Beating Heart: Early Cardiac Development in Zebrafish.Journal of cardiovascular development and disease · 2021
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Calum A MacRaeFrom Cardiovascular Medicine Division, Brigham and Women's Hospital, Departments of Medicine (C.A.M., C.E.S.) and Genetics (C.E.S.), Harvard Medical School, Boston, MA; and Howard Hughes Medical Institute, Chevy Chase, MD (C.E.S.).
Christine E SeidmanFrom Cardiovascular Medicine Division, Brigham and Women's Hospital, Departments of Medicine (C.A.M., C.E.S.) and Genetics (C.E.S.), Harvard Medical School, Boston, MA; and Howard Hughes Medical Institute, Chevy Chase, MD (C.E.S.). cseidman@genetics.med.harvard.edu.

Funding

Center for Integrated Approaches to Undiagnosed DiseasesU01HG007690 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI LOSCALZO, JOSEPH · 2014 to 2022
$10.4M
Defining Pathways from Gene Mutation to Heart FailureR01HL080494 · NHLBI · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI CHEN, CHRISTOPHER S, SEIDMAN, CHRISTINE E · 2005 to 2024
$9.4M
A Community Zebrafish Resource for Modeling GWAS BiologyR24OD017870 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOESSLING, WOLFRAM, MACRAE, CALUM A. · 2014 to 2021
$6.3M
The Genetic Basis of the GAPO Progeroid SyndromeR21AG037925 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI MACRAE, CALUM A. · 2012 to 2013
$479k
Howard Hughes Medical InstituteNHGRI NIH HHS U01 HG007690NHLBI NIH HHS R01 HL080494NIA NIH HHS R21 AG037925NIH HHS R24 OD017870
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cardiomyopathy, DilatedPrecision MedicineArrhythmias, CardiacGenotypeHumansMyofibrilsPhenotypecardiomyopathiescardiovascular diseasescell biologyEditorialsgenomicsphenotypeprecision medicine

Identifiers

PMID29038206
PMCPMC6540750

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.