Evidence map›Paper›PMID 29038129›Full record

ArticleInfection and immunity2018

Native or Proteolytically Activated NanI Sialidase Enhances the Binding and Cytotoxic Activity of Clostridium perfringens Enterotoxin and Beta Toxin.

James R Theoret, Jihong Li, Mauricio A Navarro, Jorge P Garcia, Francisco A Uzal, Bruce A McClane

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. The biology and pathogenicity ofMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. NetF-producingJournal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2020
    Review
  12. Article
  13. Article
  14. Article
  15. Sialidases FromFrontiers in cellular and infection microbiology · 2019
    Review
  16. Article
  17. Article
  18. Enterotoxic Clostridia:Microbiology spectrum · 2018
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

James R TheoretDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Jihong LiDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Mauricio A NavarroCalifornia Animal Health and Food Safety Laboratory, San Bernardino Branch, School of Veterinary Medicine, University of California-Davis, San Bernardino, California, USA.
Jorge P GarciaCalifornia Animal Health and Food Safety Laboratory, San Bernardino Branch, School of Veterinary Medicine, University of California-Davis, San Bernardino, California, USA.
Francisco A UzalCalifornia Animal Health and Food Safety Laboratory, San Bernardino Branch, School of Veterinary Medicine, University of California-Davis, San Bernardino, California, USA.
Bruce A McClaneDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA bamcc@pitt.edu.
University of California, Davis · USUniversity of Pittsburgh · US

Funding

MECHANISMS OF ACTION OF C PERFRINGENS EXTEROTOXINR01AI019844 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MC CLANE, BRUCE A · 1985 to 2024
$5.4M
Pathogenic Contributions of Clostridium perfringens NanI SialidaseR21AI125796 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LI, JIHONG, MC CLANE, BRUCE A · 2016 to 2017
$402k
NanI sialidase enhances C. perfringens host cell adherence and toxin actionR03AI105635 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LI, JIHONG · 2013 to 2014
$152k
NIAID NIH HHS R01 AI019844NIAID NIH HHS R03 AI105635NIAID NIH HHS R21 AI125796
6 · The paper itself

Abstract

Many

Indexed as

AnimalsBacterial ProteinsBacterial ToxinsCell LineClostridium perfringensEnterotoxinsHumansHuman Umbilical Vein Endothelial CellsIntestinal MucosaIntestinesMaleMiceMice, Inbred BALB CNeuraminidasePeptide HydrolasesProteolysisBacterial ProteinsBacterial Toxinsenterotoxin, ClostridiumEnterotoxinsNeuraminidasePeptide HydrolasesTrypsinVirulence Factorsbeta toxinClostridium perfringensenterotoxinsialidase

Identifiers

PMID29038129
PMCPMC5736825
OpenAlexW2766727227

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.