ReviewCold Spring Harbor perspectives in biology2018
Design Principles of Phosphorylation-Dependent Timekeeping in Eukaryotic Circadian Clocks.
Review in Cold Spring Harbor perspectives in biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Disordered but rhythmic-the role of intrinsic protein disorder in eukaryotic circadian timing.FEBS letters · 2026Review
- A membrane-driven biochemical oscillator tunable by the volume to surface area ratio.bioRxiv : the preprint server for biology · 2025Article
- PERspectives on circadian cell biology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- A Knockout of the Photoreceptor PtAureo1a Results in Altered Diel Expression of Diatom Clock Components.Plants (Basel, Switzerland) · 2024Article
- Transcriptional rewiring of an evolutionarily conserved circadian clock.The EMBO journal · 2024Article
- Article
- Article
- Glycogen metabolism is required for optimal cyanobacterial growth in the rapid light-dark cycle of low-Earth orbit.Life sciences in space research · 2023Article
- Circadian Interactomics: How Research Into Protein-Protein Interactions Beyond the Core Clock Has Influenced the Model of Circadian Timekeeping.Journal of biological rhythms · 2021Review
- Symmetry breaking meets multisite modification.eLife · 2021Article
- Translating around the clock: Multi-level regulation of post-transcriptional processes by the circadian clock.Cellular signalling · 2021Review
- Complementary phase responses via functional differentiation of dual negative feedback loops.PLoS computational biology · 2021Article
- Review
- Multiple random phosphorylations in clock proteins provide long delays and switches.Scientific reports · 2020Article
- Keeping track of time: The fundamentals of cellular clocks.The Journal of cell biology · 2020Review
- New insights into non-transcriptional regulation of mammalian core clock proteins.Journal of cell science · 2020Review
- A Systems Biology Approach Identifies Hidden Regulatory Connections Between the Circadian and Cell-Cycle Checkpoints.Frontiers in physiology · 2020Review
- Phosphorylation Hypothesis of Sleep.Frontiers in psychology · 2020Review
- Oscillations and bistability in a model of ERK regulation.Journal of mathematical biology · 2019Article
- Systems approach reveals photosensitivity and PER2 level as determinants of clock-modulator efficacy.Molecular systems biology · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The circadian clock in cyanobacteria employs a posttranslational oscillator composed of a sequential phosphorylation-dephosphorylation cycle of KaiC protein, in which the dynamics of protein structural changes driven by temperature-compensated KaiC's ATPase activity are critical for determining the period. On the other hand, circadian clocks in eukaryotes employ transcriptional feedback loops as a core mechanism. In this system, the dynamics of protein accumulation and degradation affect the circadian period. However, recent studies of eukaryotic circadian clocks reveal that the mechanism controlling the circadian period can be independent of the regulation of protein abundance. Instead, the circadian substrate is often phosphorylated at multiple sites at flexible protein regions to induce structural changes. The phosphorylation is catalyzed by kinases that induce sequential multisite phosphorylation such as casein kinase 1 (CK1) with temperature-compensated activity. We propose that the design principles of phosphorylation-dependent circadian-period determination in eukaryotes may share characteristics with the posttranslational oscillator in cyanobacteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.