ArticleNeuroImage2018
Dynamic functional connectivity impairments in early schizophrenia and clinical high-risk for psychosis.
Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
83 citing papers in PubMed, 1 synthesis or guideline pooled it, 145 citations in OpenAlex.
- Altered functional connectivity of brain regions based on a meta-analysis in patients with T2DM: A resting-state fMRI study.Brain and behavior · 2020Pooled it
- Increased regional homogeneity modulated by metacognitive training predicts therapeutic efficacy in patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2021Trial
- Altered functional connectivity of the hippocampus in cortico-subcortical networks in early-stage and emerging psychosis.European archives of psychiatry and clinical neuroscience · 2026Article
- Ecologically-Valid Emotion Signatures Enhance Mood Disorder Diagnostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Temporal dynamic changes in functional connectivity of reward network in depressed adolescents and young adults with and without suicidal attempts.BMC psychiatry · 2025Article
- Observational
- Altered Brain Network Dynamics in Schizophrenia Patients With Predominant Negative Symptoms: A Resting-State fMRI Study Using Co-Activation Pattern Analysis.Human brain mapping · 2025Article
- A Method for Estimating Dynamic Functional Network Connectivity Gradients (dFNGs) From ICA Captures Smooth Inter-Network Modulation.Human brain mapping · 2025Article
- Studying time-resolved functional connectivity via communication theory: on the complementary nature of phase synchronization and sliding window Pearson correlation.bioRxiv : the preprint server for biology · 2025Article
- Targeting the Roots of Psychosis: The Role of Aberrant Salience.Pediatric reports · 2025Review
- Neuroimage Analysis Methods and Artificial Intelligence Techniques for Reliable Biomarkers and Accurate Diagnosis of Schizophrenia: Achievements Made by Chinese Scholars Around the Past Decade.Schizophrenia bulletin · 2025Review
- Functional connectivity of subsystems of the default-mode network in patients with early psychotic symptoms.Neuroimage. Reports · 2025Article
- A Pilot Study of Adolescents with Psychotic Experiences: Potential Cerebellar Circuitry Disruption Early Along the Psychosis Spectrum.Cerebellum (London, England) · 2024Article
- Mild cognitive impairment prediction based on multi-stream convolutional neural networks.BMC bioinformatics · 2024Article
- The overlap across psychotic disorders: A functional network connectivity analysis.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2024Article
- A method for estimating dynamic functional network connectivity gradients (dFNG) from ICA captures smooth inter-network modulation.bioRxiv : the preprint server for biology · 2024Article
- Abnormal characteristic static and dynamic functional network connectivity in idiopathic normal pressure hydrocephalus.CNS neuroscience & therapeutics · 2024Article
- Article
- A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry.NeuroImage. Clinical · 2024Article
- Aberrant brain dynamics in individuals with clinical high risk of psychosis.Schizophrenia bulletin open · 2024Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
Individuals at clinical high-risk (CHR) for psychosis are characterized by attenuated psychotic symptoms. Only a minority of CHR individuals convert to full-blown psychosis. Therefore, there is a strong interest in identifying neurobiological abnormalities underlying the psychosis risk syndrome. Dynamic functional connectivity (DFC) captures time-varying connectivity over short time scales, and has the potential to reveal complex brain functional organization. Based on resting-state functional magnetic resonance imaging (fMRI) data from 70 healthy controls (HCs), 53 CHR individuals, and 58 early illness schizophrenia (ESZ) patients, we applied a novel group information guided ICA (GIG-ICA) to estimate inherent connectivity states from DFC, and then investigated group differences. We found that ESZ patients showed more aberrant connectivities and greater alterations than CHR individuals. Results also suggested that disease-related connectivity states occurred in CHR and ESZ groups. Regarding the dominant state with the highest contribution to dynamic connectivity, ESZ patients exhibited greater impairments than CHR individuals primarily in the cerebellum, frontal cortex, thalamus and temporal cortex, while CHR and ESZ populations shared common aberrances mainly in the supplementary motor area, parahippocampal gyrus and postcentral cortex. CHR-specific changes were also found in the connections between the superior frontal gyrus and calcarine cortex in the dominant state. Our findings suggest that CHR individuals generally show an intermediate functional connectivity pattern between HCs and SZ patients but also have unique connectivity alterations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.