Evidence map›Paper›PMID 29037945›Full record

ArticleBioorganic & medicinal chemistry letters2017

Enantioselective inhibitory abilities of enantiomers of notoamides against RANKL-induced formation of multinuclear osteoclasts.

Hikaru Kato, Aika Kai, Tetsuro Kawabata, James D Sunderhaus, Timothy J McAfoos, Jennifer M Finefield, Yukihiko Sugimoto, Robert M Williams, Sachiko Tsukamoto

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Metabolic bone disorders and the promise of marine osteoactive compounds.Cellular and molecular life sciences : CMLS · 2023
    Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Hikaru KatoDepartment of Natural Products, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Japan.
Aika KaiDepartment of Natural Products, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Japan.
Tetsuro KawabataDepartment of Natural Products, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Japan.
James D SunderhausDepartment of Chemistry, Colorado State University, 1301 Center Avenue, Fort Collins, CO 80523, United States.
Timothy J McAfoosDepartment of Chemistry, Colorado State University, 1301 Center Avenue, Fort Collins, CO 80523, United States.
Jennifer M FinefieldDepartment of Chemistry, Colorado State University, 1301 Center Avenue, Fort Collins, CO 80523, United States.
Yukihiko SugimotoDepartment of Pharmaceutical Biochemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Japan.
Robert M WilliamsDepartment of Chemistry, Colorado State University, 1301 Center Avenue, Fort Collins, CO 80523, United States; University of Colorado Cancer Center, Aurora, CO 80045, United States.
Sachiko TsukamotoDepartment of Natural Products, Graduate School of Pharmaceutical Sciences, Kumamoto University, Oe-honmachi 5-1, Kumamoto 862-0973, Japan. Electronic address: sachiko@kumamoto-u.ac.jp.

Funding

TOTAL SYNTHESIS AND BIOSYNTHESIS OF BIOACTIVE SUBSTANCESR01CA070375 · NCI · COLORADO STATE UNIVERSITY-FORT COLLINS · PI SHERMAN, DAVID H, WILLIAMS, ROBERT MICHAEL · 1997 to 2018
$4.4M
NCI NIH HHS R01 CA070375
6 · The paper itself

Abstract

The marine-derived Aspergillus protuberus MF297-2 and the terrestrial A. amoenus NRRL 35600 produce enantiomeric prenylated indole alkaloids. Investigation of biological activities of the natural and synthetic derivatives revealed that (-)-enantiomers of notoamides A and B, 6-epi-notoamide T, and stephacidin A inhibited receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL)-induced osteoclastogenic differentiation of murine RAW264 cells more strongly than their respective (+)-enantiomers. Among them, (-)-6-epi-notoamide T was the most potent inhibitor with an IC

Indexed as

AnimalsCell DifferentiationFungiIndole AlkaloidsInhibitory Concentration 50MiceOsteoclastsRANK LigandRAW 264.7 CellsStereoisomerismIndole Alkaloidsnotoamide Bnotoamide TRANK LigandAspergillusEnantiomerFungusNotoamideOsteoclastogenesis

Identifiers

PMID29037945
PMCPMC5909812

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.