ArticleSeminars in arthritis and rheumatism2018
Rheumatoid arthritis and risk of chronic obstructive pulmonary disease or asthma among women: A marginal structural model analysis in the Nurses' Health Study.
Article in Seminars in arthritis and rheumatism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Prevalence and risk of chronic obstructive pulmonary disease in rheumatoid arthritis: Systematic review and meta-analysis.Medicine · 2026Pooled it
- [Management of pulmonary and cardiovascular comorbidities in rheumatological diseases].Zeitschrift fur Rheumatologie · 2025Guideline
- Bidirectional association between rheumatoid arthritis and chronic obstructive pulmonary disease: a systematic review and meta-analysis.Frontiers in immunology · 2024Pooled it
- Chronic obstructive pulmonary disease in rheumatoid arthritis: a systematic review and meta-analysis.Respiratory research · 2019Pooled it
- Rheumatoid factor production is genetically and molecularly distinct from rheumatoid arthritis.The Journal of clinical investigation · 2026Article
- Discovering potential key biomarkers and molecular mechanisms in Chronic Obstructive Pulmonary Disease and rheumatoid arthritis using integrated bioinformatics and machine learning approaches.Journal, genetic engineering & biotechnology · 2026Article
- Chronic obstructive pulmonary disease (COPD) and autoimmune diseases: unravelling complex interactions.Annals of medicine · 2025Review
- Article
- Biological mechanisms of pulmonary inflammation and its association with seropositive rheumatoid arthritis.Frontiers in immunology · 2025Review
- Rheumatoid arthritis, quantitative parenchymal lung features and mortality among smokers.Rheumatology (Oxford, England) · 2025Article
- The risk of chronic obstructive pulmonary disease in patients with rheumatoid arthritis: a real-world cohort study from 136,821 patients.Frontiers in immunology · 2025Article
- Bi-directional association of rheumatoid arthritis and chronic obstructive pulmonary disease: linking arthritis, inflammation, smoking, airways disease, and emphysema.Rheumatology (Oxford, England) · 2024Article
- Combined repetitive inhalant endotoxin and collagen-induced arthritis drive inflammatory lung disease and arthritis severity in a testosterone-dependent manner.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- The association between chronic obstructive pulmonary disease and autoimmune diseases: a bidirectional Mendelian randomization study.Frontiers in medicine · 2024Article
- A Narrowing Mortality Gap: Temporal Trends of Cause-Specific Mortality in a National Matched Cohort Study in US Veterans With Rheumatoid Arthritis.Arthritis care & research · 2023Article
- Work Ability and Quality of Life in Patients with Rheumatoid Arthritis.International journal of environmental research and public health · 2022Article
- Screening for preclinical parenchymal lung disease in rheumatoid arthritis.Rheumatology (Oxford, England) · 2022Article
- Demographic, Lifestyle, and Serologic Risk Factors for Rheumatoid Arthritis (RA)-associated Bronchiectasis: Role of RA-related Autoantibodies.The Journal of rheumatology · 2022Article
- Increased susceptibility to organic dust exposure-induced inflammatory lung disease with enhanced rheumatoid arthritis-associated autoantigen expression in HLA-DR4 transgenic mice.Respiratory research · 2022Article
- Airway Disease in Rheumatoid Arthritis.Annals of the American Thoracic Society · 2022Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveWe investigated whether RA increases risk for chronic obstructive pulmonary disease (COPD) or asthma independent of factors occurring before RA onset or mediating these respiratory morbidities after diagnosis, such as cigarette smoking.
methodsWithin the prospective Nurses' Health Study (n = 121,701 women; 1976-2014), we identified an incident RA cohort and matched each woman with RA to 10 comparators without RA by age and year at index date of RA diagnosis, excluding women with COPD or asthma at baseline. Data were obtained through biennial questionnaires and medical records. We used marginal structural models to determine the independent effect of RA on incident COPD or asthma adjusting for confounders and time-varying mediators through inverse probability weighting.
resultsWe identified 843 women with RA, matched to 8,399 comparators without RA. Mean age was 59.8 years and mean follow-up after index date was 18.6 years (SD = 9.0) for women with RA, and 18.8 years (SD = 9.5) for comparators. We identified 68 (8.1%) incident COPD and 40 (4.7%) asthma cases among women with RA, and 459 (5.5%) COPD and 268 (3.2%) asthma cases among comparators. RA was associated with increased risk of COPD (HR = 1.52, 95% CI: 1.17-1.97) and asthma (HR = 1.55, 95% CI: 1.11-2.16) compared to comparators adjusted for the matching factors of age and calendar year at index date. After further adjustment for confounders and time-varying mediators occurring after index date, including smoking, RA was significantly associated with COPD (HR = 1.68, 95% CI: 1.36-2.07), but not asthma (HR = 1.11, 95% CI: 0.59-2.09) compared to non-RA comparators. Women with seropositive RA (HR = 1.60, 95% CI: 1.17-2.19) and seronegative RA (HR = 1.62, 95% CI: 1.09-2.40) had similar increased risk for COPD compared to non-RA comparators.
conclusionIn this prospective cohort study, RA was associated with increased risk for incident COPD, independent of lifestyle confounders and mediators after diagnosis, including smoking.
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