ArticleCell communication and signaling : CCS2017
A novel protein derived from lamprey supraneural body tissue with efficient cytocidal actions against tumor cells.
Article in Cell communication and signaling : CCS, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Neu5Gc-associated Serum Immunoglobulin G Glycosylation as a Diagnostic Biomarker for Hepatocellular Carcinoma.Journal of clinical and translational hepatology · 2026Article
- Identification and Functional Characterization of an Ancestral Hepcidin-Like Antimicrobial Peptide in the Lamprey (Lethenteron camtschaticum).Probiotics and antimicrobial proteins · 2026Article
- A novel serum spherical lectin from lamprey reveals a more efficient mechanism of immune initiation and regulation in jawless vertebrates.Cellular & molecular biology letters · 2022Article
- Lamprey immune protein triggers the ferroptosis pathway during zebrafish embryonic development.Cell communication and signaling : CCS · 2022Article
- Molecular Evolution of Transforming Growth Factor-β (TGF-β) Gene Family and the Functional Characterization of Lamprey TGF-β2.Frontiers in immunology · 2022Article
- MicroRNA expression profile in Lampetra morii upon Vibrio anguillarum infection and miR-4561 characterization targeting lip.Communications biology · 2021Article
- The Natterin Proteins Diversity: A Review on Phylogeny, Structure, and Immune Function.Toxins · 2021Review
- Animal secretory endolysosome channel discovery.Zoological research · 2021Review
- Lamprey Immune Protein Mediates Apoptosis of Lung Cancer Cells Via the Endoplasmic Reticulum Stress Signaling Pathway.Frontiers in oncology · 2021Article
- Molecular Characterization and Chemotactic Function of CXCL8 in Northeast Chinese Lamprey (Frontiers in immunology · 2020Article
- Molecular Evolution of Apolipoprotein Multigene Family and the Original Functional Properties of Serum Apolipoprotein (LAL2) inFrontiers in immunology · 2020Article
- Determination of the Role and Active Sites of PKC-Delta-Like from Lamprey in Innate Immunity.International journal of molecular sciences · 2019Article
- Crystal structure of a cytocidal protein from lamprey and its mechanism of action in the selective killing of cancer cells.Cell communication and signaling : CCS · 2019Article
- Reciprocal regulation of integrin β4 and KLF4 promotes gliomagenesis through maintaining cancer stem cell traits.Journal of experimental & clinical cancer research : CR · 2019Article
- Correction to: A novel protein derived from lamprey supraneural body tissue with efficient cytocidal actions against tumor cells.Cell communication and signaling : CCS · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn previous research, we found that cell secretion from the adult lamprey supraneural body tissues possesses cytocidal activity against tumor cells, but the protein with cytocidal activity was unidentified.
methodsA novel lamprey immune protein (LIP) as defense molecule was first purified and identified in jawless vertebrates (cyclostomes) using hydroxyapatite column and Q Sepharose Fast Flow column. After LIP stimulation, morphological changes of tumor cells were analysed and measured whether in vivo or in vitro.
resultsLIP induces remarkable morphological changes in tumor cells, including cell blebbing, cytoskeletal alterations, mitochondrial fragmentation and endoplasmic reticulum vacuolation, and most of the cytoplasmic and organelle proteins are released following treatment with LIP. LIP evokes an elevation of intracellular calcium and inflammatory molecule levels. Our analysis of the cytotoxic mechanism suggests that LIP can upregulate the expression of caspase 1, RIPK1, RIP3 to trigger pyroptosis and necroptosis. To examine the effect of LIP in vivo, tumor xenograft experiments were performed, and the results indicated that LIP inhibits tumor growth without damage to mice. In addition, the cytotoxic action of LIP depended on the phosphatidylserine (PS) content of the cell membrane.
conclusionsThese observations suggest that LIP plays a crucial role in tumor cell survival and growth. The findings will also help to elucidate the mechanisms of host defense in lamprey.
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