Evidence map›Paper›PMID 29037162›Full record

Trial reportBMC geriatrics2017

Feasibility of a multi-modal exercise program on cognition in older adults with Type 2 diabetes - a pilot randomised controlled trial.

M L Callisaya, R M Daly, J E Sharman, D Bruce, T M E Davis, T Greenaway, M Nolan, R Beare, M G Schultz, T Phan and 2 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC geriatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06721429 (The Effect of Dual-task Training on Balance, Exercise Capacity, Cognitive Status, and Quality of Life in Individuals With Type 2 Diabetes Mellitus), which is not on this map. Cited by 25 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06721429 narecruitingnot on this mapstarted 2024, after this paper: background citation

The Effect of Dual-task Training on Balance, Exercise Capacity, Cognitive Status, and Quality of Life in Individuals With Type 2 Diabetes Mellitus

TypeinterventionalSponsorBartın UnıversityRan2024 to 2025Enrolled36ConditionsDiabetes Mellitus, Type 2Armsdual task exercise group, single task group
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

M L CallisayaMenzies Institute for Medical Research Tasmania, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, Australia. michele.callisaya@utas.edu.au.
R M DalyInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Faculty of Health, Deakin University, Melbourne, Victoria, Australia.
J E SharmanMenzies Institute for Medical Research Tasmania, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, Australia.
D BruceMedical School, Faculty of Health and Medical Sciences, University of Western Australia Fremantle Hospital, Fremantle, Western Australia, Australia.
T M E DavisMedical School, Faculty of Health and Medical Sciences, University of Western Australia Fremantle Hospital, Fremantle, Western Australia, Australia.
T GreenawayMenzies Institute for Medical Research Tasmania, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, Australia.
M NolanMenzies Institute for Medical Research Tasmania, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, Australia.
R BeareStroke and Aging Research Group, Department of Medicine, Southern Clinical School, Monash University, Clayton, Victoria, Australia.
M G SchultzMenzies Institute for Medical Research Tasmania, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, Australia.
T PhanStroke and Aging Research Group, Department of Medicine, Southern Clinical School, Monash University, Clayton, Victoria, Australia.
L C BlizzardMenzies Institute for Medical Research Tasmania, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, Australia.
V K SrikanthMenzies Institute for Medical Research Tasmania, University of Tasmania, 17 Liverpool Street, Hobart, Tasmania, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundType 2 Diabetes (T2D) is associated with increased risk of dementia. We aimed to determine the feasibility of a randomised controlled trial (RCT) examining the efficacy of exercise on cognition and brain structure in people with T2D.

methodsA 6-month pilot parallel RCT of a progressive aerobic- and resistance-training program versus a gentle movement control group in people with T2D aged 50-75 years (n = 50) at the University of Tasmania, Australia. Assessors were blinded to group allocation. Brain volume (total, white matter, hippocampus), cortical thickness and white matter microstructure (fractional anisotrophy and mean diffusivity) were measured using magnetic resonance imaging, and cognition using a battery of neuropsychological tests. Study design was assessed by any changes (during the pilot or recommended) to the protocol, recruitment by numbers screened and time to enrol 50 participants; randomisation by similarity of characteristics in groups at baseline, adherence by exercise class attendance; safety by number and description of adverse events and retention by numbers withdrawn.

resultsThe mean age of participants was 66.2 (SD 4.9) years and 48% were women. There were no changes to the design during the study. A total of 114 people were screened for eligibility, with 50 participants with T2D enrolled over 8 months. Forty-seven participants (94%) completed the study (23 of 24 controls; 24 of 26 in the intervention group). Baseline characteristics were reasonably balanced between groups. Exercise class attendance was 79% for the intervention and 75% for the control group. There were 6 serious adverse events assessed as not or unlikely to be due to the intervention. Effect sizes for each outcome variable are provided.

conclusionThis study supports the feasibility of a large scale RCT to test the benefits of multi-modal exercise to prevent cognitive decline in people with T2D. Design changes to the future trial are provided.

trial registrationANZCTR 12614000222640 ; Registered 3/3/2014; First participant enrolled 26/6/2014, study screening commenced 1/9/2014; Australian and New Zealand Clinical Trial Registry.

Indexed as

Exercise TherapyAgedBrainCognition DisordersDementiaDiabetes Mellitus, Type 2ExerciseFeasibility StudiesFemaleHumansMaleMiddle AgedPilot ProjectsResistance TrainingCognitionDementiaExerciseInterventionMRI brainType 2 diabetes

Identifiers

PMID29037162
PMCPMC5644140

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.