ArticleBMC bioinformatics2017
chngpt: threshold regression model estimation and inference.
Article in BMC bioinformatics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 1 of them a synthesis that pooled it.
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Who cites it
81 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Critical thresholds for co-benefits of carbon accumulation and biodiversity conservation under global nitrogen enrichment.Nature communications · 2026Pooled it
- Clinical and biomarker modifiers of vitamin D treatment response: the Multi-Ethnic Study of Atherosclerosis.The American journal of clinical nutrition · 2022Trial
- Trial
- Neutralizing Antibody Correlates Analysis of Tetravalent Dengue Vaccine Efficacy Trials in Asia and Latin America.The Journal of infectious diseases · 2018Trial
- Increasing risk of vapor pressure deficit exceeding critical thresholds for tree growth.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Adenoid-Nasopharyngeal Ratio and craniofacial growth in Children: A two-center longitudinal study with threshold and causal analyses.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Long-term effects of clear-cutting forestry on ectomycorrhizal fungi in boreal forest.The New phytologist · 2026Article
- Microbial Functional Genes Help Explain Soil Carbon Sensitivity to Temperature Across Global Biomes.Global change biology · 2026Article
- A novel approach for sampling plant mass-density relationships.Fundamental research · 2026Article
- Alzheimer's disease and cerebrovascular biomarkers in relation to odor identification in a naturalistic clinical cohort.Alzheimer's research & therapy · 2026Article
- Divergent mechanisms governing aboveground biomass in desert plants across a drought gradient.iScience · 2026Article
- Association between body roundness index and reproductive outcomes in patients with polycystic ovary syndrome: a secondary analysis based on PCOSAct.Frontiers in nutrition · 2026Article
- The impacts of China's low-carbon technology trade on modern energy access in Africa: the role of domestic absorptive capacity.Scientific reports · 2025Article
- Association Between Differential Heterogeneity of Antibiotics Consumption and Share of Resistant Pathogens and Its Implication for Antibiotic Stewardship in a German Hospital Intensive Care Unit.Antibiotics (Basel, Switzerland) · 2025Article
- Beyond Estrogen Deficiency: The Independent Role of FSH in Site-Specific Bone Loss in Midlife Women.Calcified tissue international · 2025Article
- SplitWise regression for capturing nonlinear effects in interpretable model selection.Scientific reports · 2025Article
- Sequential Thresholds Shape Drylands' Multitrophic Response to Aridification.Ecology letters · 2025Article
- Highly protected areas buffer against aridity thresholds in global drylands.Nature plants · 2025Article
- Observational
- A reaction norm for flowering time plasticity reveals physiological footprints of maize adaptation.G3 (Bethesda, Md.) · 2025Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
backgroundThreshold regression models are a diverse set of non-regular regression models that all depend on change points or thresholds. They provide a simple but elegant and interpretable way to model certain kinds of nonlinear relationships between the outcome and a predictor.
resultsThe R package chngpt provides both estimation and hypothesis testing functionalities for four common variants of threshold regression models. All allow for adjustment of additional covariates not subjected to thresholding. We demonstrate the consistency of the estimating procedures and the type 1 error rates of the testing procedures by Monte Carlo studies, and illustrate their practical uses using an example from the study of immune response biomarkers in the context of Mother-To-Child-Transmission of HIV-1 viruses.
conclusionchngpt makes several unique contributions to the software for threshold regression models and will make these models more accessible to practitioners interested in modeling threshold effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.