Evidence map›Paper›PMID 29037107›Full record

Trial reportMolecular imaging

First-in-Man Evaluation of

Richard Laforest, Farrokh Dehdashti, Yongjian Liu, Jennifer Frye, Sarah Frye, Hannah Luehmann, Deborah Sultan, Joseph S Shan, Bruce D Freimark, Barry A Siegel

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in Molecular imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Advances and challenges in immunoPET methodology.Frontiers in nuclear medicine · 2024
    Review
  4. Review
  5. Review
  6. Article
  7. Interest and Limits of [Frontiers in oncology · 2021
    Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Richard Laforest1 Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.
Farrokh Dehdashti2 Alvin J. Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, USA.
Yongjian Liu1 Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.
Jennifer Frye3 Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.
Sarah Frye3 Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.
Hannah Luehmann1 Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.
Deborah Sultan1 Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.
Joseph S Shan4 Peregrine Pharmaceuticals Inc, Tustin, CA, USA.
Bruce D Freimark4 Peregrine Pharmaceuticals Inc, Tustin, CA, USA.
Barry A Siegel2 Alvin J. Siteman Cancer Center, Washington University School of Medicine, St Louis, MO, USA.
Mallinckrodt (United States) · USAvid Bioservices (United States) · USAlvin J. Siteman Cancer Center

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePGN650 is a F(ab')

methodsEleven patients with known solid tumors received approximately 140 MBq (3.8 mCi)

resultsKnown tumor foci demonstrated mildly increased uptake, with the highest activity at the latest imaging time. There were no unexpected adverse events. The liver was the organ receiving the highest radiation dose (0.77 mGy/MBq); the effective dose was 0.41 mSv/MBq.

conclusionAlthough

Indexed as

Positron-Emission TomographyTumor MicroenvironmentAdultAgedAnimalsBiomarkers, TumorDemographyDose-Response Relationship, RadiationFemaleHumansIodine RadioisotopesMaleMiddle AgedNeoplasmsPhosphatidylserinesPositron Emission Tomography Computed TomographyBiomarkers, TumorIodine-124Iodine RadioisotopesPhosphatidylserinesRadiopharmaceuticalsapoptosiscancerdosimetryhuman imagingPET

Identifiers

PMID29037107
PMCPMC5648081
OpenAlexW2765767118

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.