ArticleBiomacromolecules2017
Porous Poly(ε-caprolactone)-Poly(l-lactic acid) Semi-Interpenetrating Networks as Superior, Defect-Specific Scaffolds with Potential for Cranial Bone Defect Repair.
Article in Biomacromolecules, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Impact of E-Beam Sterilization on Bioglass Composite Shape Memory Scaffolds.Macromolecular materials and engineering · 2026Article
- Hybrid Chitosan/PCL Shape Memory Scaffolds with Potential for Bone Regeneration and Infection Resistance.ACS biomaterials science & engineering · 2025Article
- 4D fabrication of shape-changing systems for tissue engineering: state of the art and perspectives.Progress in additive manufacturing · 2025Review
- An In Vivo Assessment of Different Mesenchymal Stromal Cell Tissue Types and Their Differentiation State on a Shape Memory Polymer Scaffold for Bone Regeneration.Journal of biomedical materials research. Part B, Applied biomaterials · 2024Article
- Shape Memory Polymer Scaffolds-Utility for In Vitro Osteogenesis of Canine Multipotent Stromal Cells.Journal of biomedical materials research. Part B, Applied biomaterials · 2024Article
- Polycaprolactone-based shape memory foams as self-fitting vaginal stents.Acta biomaterialia · 2024Article
- Mechanically robust and personalized silk fibroin-magnesium composite scaffolds with water-responsive shape-memory for irregular bone regeneration.Nature communications · 2024Article
- Trends in bioactivity: inducing and detecting mineralization of regenerative polymeric scaffolds.Journal of materials chemistry. B · 2024Review
- 3D-printed placental-derived bioinks for skin tissue regeneration with improved angiogenesis and wound healing properties.Materials today. Bio · 2023Article
- An anti-bacterial porous shape memory self-adaptive stiffened polymer for alveolar bone regeneration after tooth extraction.Bioactive materials · 2023Article
- The Current Status, Prospects, and Challenges of Shape Memory Polymers Application in Bone Tissue Engineering.Polymers · 2023Review
- Existing and Novel Biomaterials for Bone Tissue Engineering.International journal of molecular sciences · 2022Review
- Evaluation of a self-fitting, shape memory polymer scaffold in a rabbit calvarial defect model.Acta biomaterialia · 2021Article
- Suitability of EtO Sterilization for Polydopamine-coated, Self-fitting Bone Scaffolds.Polymer degradation and stability · 2021Article
- Intrinsic osteoinductivity of PCL-DA/PLLA semi-IPN shape memory polymer scaffolds.Journal of biomedical materials research. Part A · 2021Article
- Smart scaffolds: shape memory polymers (SMPs) in tissue engineering.Journal of materials chemistry. B · 2021Article
- Shape memory polymer (SMP) scaffolds with improved self-fitting properties.Journal of materials chemistry. B · 2021Article
- A review of biomimetic scaffolds for bone regeneration: Toward a cell-free strategy.Bioengineering & translational medicine · 2021Review
- Bioactive Siloxane-Containing Shape-Memory Polymer (SMP) Scaffolds with Tunable Degradation Rates.ACS biomaterials science & engineering · 2021Article
- PCL-Based Shape Memory Polymer Semi-IPNs: The Role of Miscibility in Tuning the Degradation Rate.Biomacromolecules · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The treatment of irregular cranial bone defects is currently limited due to the graft resorption that can occur when an ill-fitting interface exists between an autograft and the surrounding tissue. A tissue engineering scaffold able to achieve defect-specific geometries could improve healing. This work reports a macroporous, shape memory polymer (SMP) scaffold composed of a semi-interpenetrating network (semi-IPN) of thermoplastic poly(l-lactic acid) (PLLA) within cross-linked poly(ε-caprolactone) diacrylate (PCL-DA) that is capable of conformal fit within a defect. The macroporous scaffolds were fabricated using a fused salt template and were also found to have superior, highly controlled properties needed for regeneration. Specifically, the scaffolds displayed interconnected pores, improved rigidity, and controlled, accelerated degradation. Although slow degradation rates of scaffolds can limit healing, the unique degradation behavior observed could prove promising. Thus, the described SMP semi-IPN scaffolds overcome two of the largest limitations in bone tissue engineering: defect "fit" and tailored degradation.
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Registered trials
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