Evidence map›Paper›PMID 29036785›Full record

ArticleCancer biomarkers : section A of Disease markers2017

Wide-transcriptome analysis and cellularity of bone marrow CD34+/lin- cells of patients with chronic-phase chronic myeloid leukemia at diagnosis vs. 12 months of first-line nilotinib treatment.

Alessandra Trojani, Ester Pungolino, Giuseppe Rossi, Mariella D'Adda, Milena Lodola, Barbara Di Camillo, Alessandra Perego, Mauro Turrini, Ester Orlandi, Lorenza Borin and 11 more

Abstract readMulticenter Study
In one paragraph

Article in Cancer biomarkers : section A of Disease markers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Alessandra TrojaniDivision of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Ester PungolinoDivision of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Giuseppe RossiDepartment of Hematology, ASST Spedali Civili, Brescia, Italy.
Mariella D'AddaDepartment of Hematology, ASST Spedali Civili, Brescia, Italy.
Milena LodolaDivision of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Barbara Di CamilloDepartment of Information Engineering, University of Padova, Padova, Italy.
Alessandra PeregoInternal Medicine-Haematology, Desio Hospital, Desio, Italy.
Mauro TurriniDivision of Hematology, Department of Internal Medicine, Valduce Hospital, Como, Italy.
Ester OrlandiHematology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Lorenza BorinHematology Division, San Gerardo Hospital, Monza, Italy.
Alessandra IurloOncohematology Division, IRCCS Ca' Granda - Maggiore Policlinico Hospital Foundation, Milano, Italy.
Simona MalatoHematology and Bone Marrow Transplantation Unit, San Raffaele Scientific Institute, Milano, Italy.
Francesco SpinaDivision of Hematology - Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy.
Maria Luisa LatargiaASST Valle Olona Ospedale di Circolo, Busto Arsizio, Italy.
Francesco LanzaDivision of Hematology, Hospital of Cremona, Cremona, Italy.
Salvatore ArtaleASST Valle Olona Sant'Antonio Abate, Gallarate, Italy.
Michela AnghilieriASST Lecco, Lecco, Italy.
Maria Cristina CarraroHematology and Transfusion Medicine, Sacco Hospital, Milano, Italy.
Gabriella De CanalPathology Department, Cytogenetics, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.
Enrica MorraExecutive Committee, Rete Ematologia Lombarda, Italy.
Roberto CairoliDivision of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder with heterogeneous biological and clinical features. The biomolecular mechanisms of CML response to tyrosine-kinase inhibitors are not fully defined.

objectiveWe undertook a gene expression profiling (GEP) study of selected bone marrow (BM) CD34+/lin- cells of chronic-phase CML patients at diagnosis and after 12 months of TKI nilotinib to investigate molecular signatures characterizing both conditions.

Indexed as

Antigens, CD34Bone Marrow CellsGene Expression ProfilingGene Expression Regulation, LeukemicHumansLeukemia, Myeloid, Chronic-PhaseLeukocyte CountProtein-Tyrosine KinasesPyrimidinesTime FactorsTreatment OutcomeAntigens, CD34nilotinibProtein-Tyrosine KinasesPyrimidines

Identifiers

PMID29036785
PMCPMC13075758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.