ArticleSchizophrenia bulletin2018
Latent Profile Analysis and Conversion to Psychosis: Characterizing Subgroups to Enhance Risk Prediction.
Article in Schizophrenia bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Negative Symptoms and Functioning in Youth at Risk of Psychosis: A Systematic Review and Meta-analysis.Harvard review of psychiatryPooled it
- Dynamic, differentiated clinical trajectories and prediction in clinical high risk for psychosis.Molecular psychiatry · 2026Article
- Elevated defeatist performance beliefs predict state increases in negative symptoms in daily life in clinical high-risk for psychosis youth: implications for mobile health treatments.European archives of psychiatry and clinical neuroscience · 2026Article
- Association Between Social and Role Functioning and Transition to Psychosis in the North American Prodrome Longitudinal Study Consortium.Schizophrenia bulletin · 2026Article
- Salience network segregation and symptom profiles in psychosis risk subgroups among youth and early adults.Schizophrenia (Heidelberg, Germany) · 2025Article
- Patterns of suicidal thoughts and behaviors in depressed adolescents with and without psychotic features.Psychiatry research · 2025Article
- Probabalistic reinforcement learning impairments predict negative symptom severity and risk for conversion in youth at clinical high-risk for psychosis.Psychological medicine · 2025Article
- A generalized reward processing deficit pathway to negative symptoms across diagnostic boundaries.Psychological medicine · 2025Article
- Identifying neurobiological heterogeneity in clinical high-risk psychosis: a data-driven biotyping approach using resting-state functional connectivity.Schizophrenia (Heidelberg, Germany) · 2025Article
- Three-year course of clinical high-risk symptoms for psychosis in the community: a latent class analysis.Epidemiology and psychiatric sciences · 2025Article
- Environmental context predicts state fluctuations in negative symptoms in youth at clinical high risk for psychosis.Psychological medicine · 2023Article
- Negative Symptom Trajectories in Individuals at Clinical High Risk for Psychosis: Differences Based on Deficit Syndrome, Persistence, and Transition Status.Schizophrenia bulletin open · 2023Article
- Cognitive-Behavioral Social Skills Training: Outcome of a Randomized Controlled Trial for Youth at Risk of Psychosis.Schizophrenia bulletin open · 2023Article
- Clinical, Brain, and Multilevel Clustering in Early Psychosis and Affective Stages.JAMA psychiatry · 2022Article
- Further evidence that antipsychotic medication does not prevent long-term psychosis in higher-risk individuals.European archives of psychiatry and clinical neuroscience · 2022Article
- A systematic review of premorbid cognitive functioning and its timing of onset in schizophrenia spectrum disorders.Schizophrenia research. Cognition · 2022Article
- Antipsychotic prescription, assumption and conversion to psychosis: resolving missing clinical links to optimize prevention through precision.Schizophrenia (Heidelberg, Germany) · 2022Article
- A Latent Profile Analysis of Psychotic Experiences, Non-psychotic Symptoms, Suicidal Ideation and Underlying Mechanisms in a Sample of Adolescents From the General Population.Frontiers in psychiatry · 2022Article
- Persons with first episode psychosis have distinct profiles of social cognition and metacognition.NPJ schizophrenia · 2021Article
- The COVID-19 Pandemic Introduces Diagnostic and Treatment Planning Complexity for Individuals at Clinical High Risk for Psychosis.Schizophrenia bulletin · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundGroups at clinical high risk (CHR) of developing psychosis are heterogeneous, composed of individuals with different clusters of symptoms. It is likely that there exist subgroups, each associated with different symptom constellations and probabilities of conversion.
methodPresent study used latent profile analysis (LPA) to ascertain subgroups in a combined sample of CHR (n = 171) and help-seeking controls (HSCs; n = 100; PREDICT study). Indicators in the LPA model included baseline Scale of Prodromal Symptoms (SOPS), Calgary Depression Scale for Schizophrenia (CDSS), and neurocognitive performance as measured by multiple instruments, including category instances (CAT). Subgroups were further characterized using covariates measuring demographic and clinical features.
resultsThree classes emerged: class 1 (mild, transition rate 5.6%), lowest SOPS and depression scores, intact neurocognitive performance; class 2 (paranoid-affective, transition rate 14.2%), highest suspiciousness, mild negative symptoms, moderate depression; and class 3 (negative-neurocognitive, transition rate 29.3%), highest negative symptoms, neurocognitive impairment, social cognitive impairment. Classes 2 and 3 evidenced poor social functioning.
conclusionsResults support a subgroup approach to research, assessment, and treatment of help-seeking individuals. Class 3 may be an early risk stage of developing schizophrenia.
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