ArticleSchizophrenia bulletin2018
Lack of Diagnostic Pluripotentiality in Patients at Clinical High Risk for Psychosis: Specificity of Comorbidity Persistence and Search for Pluripotential Subgroups.
Article in Schizophrenia bulletin, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- On the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis.Molecular psychiatry · 2024Pooled it
- Immune and oxidative stress biomarkers in pediatric psychosis and psychosis-risk: Meta-analyses and systematic review.Brain, behavior, and immunity · 2024Pooled it
- Neuropsychological Performance Among Individuals at Clinical High-Risk for Psychosis vs Putatively Low-Risk Peers With Other Psychopathology: A Systematic Review and Meta-Analysis.Schizophrenia bulletin · 2022Pooled it
- Can We Predict Psychosis Outside the Clinical High-Risk State? A Systematic Review of Non-Psychotic Risk Syndromes for Mental Disorders.Schizophrenia bulletin · 2018Pooled it
- Exploring the Relationship Between Inflammatory Biomarkers and Negative Symptoms Subtypes in Individuals at Ultra-High Risk for Psychosis.Early intervention in psychiatry · 2026Article
- Value representation in youth psychopathology: evidence of a transdiagnostic risk mechanism for psychosis.Translational psychiatry · 2026Article
- Feasibility of a Stepped-Care Intervention for Those at Clinical High Risk for Psychosis in the United States.Early intervention in psychiatry · 2026Article
- Emergence and Dynamics of Delusions and Hallucinations Across Stages in Early Psychosis.Biological psychiatry · 2025Article
- Shift in sex and age of individuals at a clinical high risk (CHR) for psychosis: relation to differences in recruitment methods and effect on sample characteristics.Schizophrenia (Heidelberg, Germany) · 2025Article
- Implementing Learning Health System Principles to Advance the Evaluation and Treatment of Clinical High-Risk for Psychosis.medRxiv : the preprint server for health sciences · 2025Article
- Non-psychotic Outcomes in Young People at Ultra-High Risk of Developing a Psychotic Disorder: A Long-Term Follow-up Study.Schizophrenia bulletin · 2024Article
- Psychosis superspectrum I: Nosology, etiology, and lifespan development.Molecular psychiatry · 2024Review
- Exploring the complex relationships between coping strategies, locus of control and self-esteem with psychopathology: structural equation modeling with a special focus on clinical high-risk of psychosis.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- Clinical high-risk criteria of psychosis in 8-17-year-old community subjects and inpatients not suspected of developing psychosis.World journal of psychiatry · 2022Article
- Impact of Comorbid Affective Disorders on Longitudinal Clinical Outcomes in Individuals at Ultra-high Risk for Psychosis.Schizophrenia bulletin · 2022Article
- Short-term functional outcome in psychotic patients: results of the Turku early psychosis study (TEPS).BMC psychiatry · 2021Article
- Establishing a clinical high-risk program in Tunisia, North Africa: A pilot study in early detection and identification.Early intervention in psychiatry · 2021Article
- White matter changes in psychosis risk relate to development and are not impacted by the transition to psychosis.Molecular psychiatry · 2021Article
- Depression: An actionable outcome for those at clinical high-risk.Schizophrenia research · 2021Article
- Computerized Assessment of Psychosis Risk.Journal of psychiatry and brain science · 2021Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
More than 20 years after the clinical high risk syndrome for psychosis (CHR) was first articulated, it remains controversial whether the CHR syndrome predicts onset of psychosis with diagnostic specificity or predicts pluripotential diagnostic outcomes. Recently, analyses of observational studies, however, have suggested that the CHR syndrome is not pluripotential for emergent diagnostic outcomes. The present report conducted additional analyses in previously reported samples to determine (1) whether comorbid disorders were more likely to persist in CHR patients compared to a comparison group of patients who responded to CHR recruitment efforts but did not meet criteria, termed help-seeking comparison subjects (HSC); and (2) whether clinically defined pluripotential CHR subgroups could be identified. All data were derived from 2 multisite studies in which DSM-IV structured diagnostic interviews were conducted at baseline and at 6-month intervals. Across samples we observed persistence of any nonpsychotic disorder in 80/147 CHR cases (54.4%) and in 48/84 HSC cases (57.1%, n.s.). Findings with persistence of anxiety, depressive, and bipolar disorders considered separately were similar. Efforts to discover pluripotential CHR subgroups were unsuccessful. These findings add additional support to the view that the CHR syndrome is not pluripotential for predicting various diagnostic outcomes but rather is specific for predicting emergent psychosis.
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