ArticleJournal of the American Medical Informatics Association : JAMIA2018
Uncovering exposures responsible for birth season - disease effects: a global study.
Article in Journal of the American Medical Informatics Association : JAMIA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 7 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Securing Federated Learning With Blockchain in the Medical Field: Systematic Literature Review.Journal of medical Internet research · 2026Pooled it
- Impacts of heat exposure in utero on long-term health and social outcomes: a systematic review.BMC pregnancy and childbirth · 2024Pooled it
- Prenatal ambient temperature and risk for schizophrenia.Schizophrenia research · 2022Pooled it
- Month of birth and mental disorders: A population-based study and validation using global meta-analysis.Acta psychiatrica Scandinavica · 2021Pooled it
- Pooled it
- How 25(OH)D Levels during Pregnancy Affect Prevalence of Autism in Children: Systematic Review.Nutrients · 2020Pooled it
- Female Reproductive Performance and Maternal Birth Month: A Comprehensive Meta-Analysis Exploring Multiple Seasonal Mechanisms.Scientific reports · 2020Pooled it
- Pushing your luck: on chance, serendipity, and athlete development.Sports medicine - open · 2025Article
- Capacity Planning (Capital, Staff and Costs) of Inpatient Maternity Services: Pitfalls for the Unwary.International journal of environmental research and public health · 2025Article
- Uncovering Important Diagnostic Features for Alzheimer's, Parkinson's and Other Dementias Using Interpretable Association Mining Methods.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2025Article
- Determining the Importance of Clinical Modalities for NeuroDegenerative Disorders and Risk of Patient Injury Using Machine Learning and Survival Analysis.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2025Article
- Distributed learning for heterogeneous clinical data with application to integrating COVID-19 data across 230 sites.NPJ digital medicine · 2022Article
- An efficient and accurate distributed learning algorithm for modeling multi-site zero-inflated count outcomes.Scientific reports · 2021Article
- Harnessing electronic health records to study emerging environmental disasters: a proof of concept with perfluoroalkyl substances (PFAS).NPJ digital medicine · 2021Article
- Weight-Based Framework for Predictive Modeling of Multiple Databases With Noniterative Communication Without Data Sharing: Privacy-Protecting Analytic Method for Multi-Institutional Studies.JMIR medical informatics · 2021Article
- The Relationship Between Children's Birth Time and Short Stature.Frontiers in pediatrics · 2021Article
- Learning from local to global: An efficient distributed algorithm for modeling time-to-event data.Journal of the American Medical Informatics Association : JAMIA · 2020Article
- Learning from electronic health records across multiple sites: A communication-efficient and privacy-preserving distributed algorithm.Journal of the American Medical Informatics Association : JAMIA · 2020Article
- Applied Veterinary Informatics: Development of a Semantic and Domain-Specific Method to Construct a Canine Data Repository.Scientific reports · 2019Article
- Combining Nonclinical Determinants of Health and Clinical Data for Research and Evaluation: Rapid Review.JMIR public health and surveillance · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 8 institutions in 3 countries.
Funding
Abstract
objectiveBirth month and climate impact lifetime disease risk, while the underlying exposures remain largely elusive. We seek to uncover distal risk factors underlying these relationships by probing the relationship between global exposure variance and disease risk variance by birth season. MATERIAL AND
methodsThis study utilizes electronic health record data from 6 sites representing 10.5 million individuals in 3 countries (United States, South Korea, and Taiwan). We obtained birth month-disease risk curves from each site in a case-control manner. Next, we correlated each birth month-disease risk curve with each exposure. A meta-analysis was then performed of correlations across sites. This allowed us to identify the most significant birth month-exposure relationships supported by all 6 sites while adjusting for multiplicity. We also successfully distinguish relative age effects (a cultural effect) from environmental exposures.
resultsAttention deficit hyperactivity disorder was the only identified relative age association. Our methods identified several culprit exposures that correspond well with the literature in the field. These include a link between first-trimester exposure to carbon monoxide and increased risk of depressive disorder (R = 0.725, confidence interval [95% CI], 0.529-0.847), first-trimester exposure to fine air particulates and increased risk of atrial fibrillation (R = 0.564, 95% CI, 0.363-0.715), and decreased exposure to sunlight during the third trimester and increased risk of type 2 diabetes mellitus (R = -0.816, 95% CI, -0.5767, -0.929).
conclusionA global study of birth month-disease relationships reveals distal risk factors involved in causal biological pathways that underlie them.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.