Evidence map›Paper›PMID 29036351›Full record

ArticleNucleic acids research2018

miRandola 2017: a curated knowledge base of non-invasive biomarkers.

Francesco Russo, Sebastiano Di Bella, Federica Vannini, Gabriele Berti, Flavia Scoyni, Helen V Cook, Alberto Santos, Giovanni Nigita, Vincenzo Bonnici, Alessandro Laganà and 9 more

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Online Databases in Circular RNAs.Advances in experimental medicine and biology · 2025
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Exploring Circular RNA Profile and Expression in Extracellular Vesicles.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 4 countries.

Francesco RussoDisease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Sebastiano Di BellaBusiness Unit Oncology, Nerviano Medical Sciences, Milan, 20014, Italy.
Federica VanniniInstitute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, 56127, Italy.
Gabriele BertiInstitute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, 56127, Italy.
Flavia ScoyniUniversity of Eastern Finland, Kuopio, 72010, Finland.
Helen V CookDisease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Alberto SantosDisease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Giovanni NigitaDepartment of Cancer Biology and Genetics, The Ohio State University, OH 43210, USA.
Vincenzo BonniciDepartment of Computer Science, University of Verona, Verona, 37134, Italy.
Alessandro LaganàDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029-6574, USA.
Filippo GeraciInstitute of Informatics and Telematics (IIT), National Research Council (CNR), Pisa, 56124, Italy.
Alfredo PulvirentiDepartment of Clinical and Experimental Medicine, University of Catania, Catania, 95125, Italy.
Rosalba GiugnoDepartment of Computer Science, University of Verona, Verona, 37134, Italy.
Federico De MasiDepartment of Bio and Health Informatics, DTU Bioinformatics, Technical University of Denmark, Lyngby, 2800, Denmark.
Kirstine BellingDisease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Lars J JensenDisease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Søren BrunakDisease Systems Biology, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Marco PellegriniInstitute of Informatics and Telematics (IIT), National Research Council (CNR), Pisa, 56124, Italy.
Alfredo FerroDepartment of Clinical and Experimental Medicine, University of Catania, Catania, 95125, Italy.
University of Copenhagen · DKInstitute of Informatics and Telematics · ITScuola Superiore Sant'Anna · ITUniversity of Catania · ITUniversity of Verona · ITIcahn School of Medicine at Mount Sinai · USNerviano Medical Sciences · ITTechnical University of Denmark · DKThe Ohio State University · USUniversity of Eastern Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

miRandola (http://mirandola.iit.cnr.it/) is a database of extracellular non-coding RNAs (ncRNAs) that was initially published in 2012, foreseeing the relevance of ncRNAs as non-invasive biomarkers. An increasing amount of experimental evidence shows that ncRNAs are frequently dysregulated in diseases. Further, ncRNAs have been discovered in different extracellular forms, such as exosomes, which circulate in human body fluids. Thus, miRandola 2017 is an effort to update and collect the accumulating information on extracellular ncRNAs that is spread across scientific publications and different databases. Data are manually curated from 314 articles that describe miRNAs, long non-coding RNAs and circular RNAs. Fourteen organisms are now included in the database, and associations of ncRNAs with 25 drugs, 47 sample types and 197 diseases. miRandola also classifies extracellular RNAs based on their extracellular form: Argonaute2 protein, exosome, microvesicle, microparticle, membrane vesicle, high density lipoprotein and circulating. We also implemented a new web interface to improve the user experience.

Indexed as

Databases, GeneticKnowledge BasesRNA, UntranslatedBiomarkersCell-Free Nucleic AcidsData CurationHumansMicroRNAsRNARNA, CircularRNA, Long NoncodingUser-Computer InterfaceBiomarkersCell-Free Nucleic AcidsMicroRNAsRNARNA, CircularRNA, Long NoncodingRNA, Untranslated

Identifiers

PMID29036351
PMCPMC5753291
OpenAlexW2758610627

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.