Evidence map›Paper›PMID 29036291›Full record

ArticleBioinformatics (Oxford, England)2017

Phylotyper: in silico predictor of gene subtypes.

Matthew D Whiteside, Victor P J Gannon, Chad R Laing

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Multi-Year Persistence of VerotoxigenicFrontiers in microbiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Matthew D WhitesideNational Microbiology Laboratory, Public Health Agency of Canada, Lethbridge, AB T1J 3Z4, Canada.
Victor P J GannonNational Microbiology Laboratory, Public Health Agency of Canada, Lethbridge, AB T1J 3Z4, Canada.
Chad R LaingNational Microbiology Laboratory, Public Health Agency of Canada, Lethbridge, AB T1J 3Z4, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

summaryWhole genome sequencing (WGS) is being adopted in public health for improved surveillance and outbreak analysis. In public health, subtyping has been used to infer phenotypes and distinguish bacterial strain groups. In silico tools that predict subtypes from sequences data are needed to transition historical data to WGS-based protocols. Phylotyper is a novel solution for in silico subtype prediction from gene sequences. Designed for incorporation into WGS pipelines, it is a general prediction tool that can be applied to different subtype schemes. Phylotyper uses phylogeny to model the evolution of the subtype and infer subtypes for unannotated sequences. The phylogenic framework in Phylotyper improves accuracy over approaches based solely on sequence similarity and provides useful contextual feedback. AVAILABILITY AND IMPLEMENTATION: Phylotyper is a python and R package. It is available from: https://github.com/superphy/insilico-subtyping. CONTACT: matthew.whiteside@phac-aspc.gc.ca. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Indexed as

Computer SimulationPhylogenyBacteriaBacterial InfectionsBiological EvolutionDisease OutbreaksGenomicsHumansModels, GeneticPhenotypeSoftwareWhole Genome Sequencing

Identifiers

PMID29036291
PMCPMC5870578

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.