ArticlePLoS neglected tropical diseases2017
Substantial population structure of Plasmodium vivax in Thailand facilitates identification of the sources of residual transmission.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- High Prevalence, Genetic Diversity and Temporal Differentiation of Plasmodium vivax in a Remote Hard-to-Reach Community from the Peruvian Amazon Region.The American journal of tropical medicine and hygiene · 2025Article
- Molecular epidemiology and genetic diversity of disappearing Plasmodium vivax in southern Thailand.Scientific reports · 2025Article
- Population genetics ofFrontiers in genetics · 2025Article
- Plasmodium vivax populations in the western Greater Mekong Subregion evaluated using a genetic barcode.PLoS neglected tropical diseases · 2024Article
- Low Genetic Diversity ofTropical medicine and infectious disease · 2024Article
- Analytic Approaches in Genomic Epidemiological Studies of Parasitic Protozoa.Transboundary and emerging diseases · 2024Review
- Genetic diversity and molecular evolution of Plasmodium vivax Duffy Binding Protein and Merozoite Surface Protein-1 in northwestern Thailand.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2023Article
- Multidisciplinary Investigations of Sustained Malaria Transmission in the Greater Mekong Subregion.The American journal of tropical medicine and hygiene · 2022Article
- Population genomics in neglected malaria parasites.Frontiers in microbiology · 2022Review
- Low parasite connectivity among three malaria hotspots in Thailand.Scientific reports · 2021Article
- Spatial and genetic clustering of Plasmodium falciparum and Plasmodium vivax infections in a low-transmission area of Ethiopia.Scientific reports · 2020Article
- Population genomics identifies a distinct Plasmodium vivax population on the China-Myanmar border of Southeast Asia.PLoS neglected tropical diseases · 2020Article
- Dynamics of Plasmodium vivax populations in border areas of the Greater Mekong sub-region during malaria elimination.Malaria journal · 2020Article
- Population Genetic Analysis of theFrontiers in microbiology · 2020Article
- NewFrontiers in microbiology · 2020Article
- Genetic Diversity of Plasmodium vivax in Clinical Isolates from Southern Thailand using PvMSP1, PvMSP3 (PvMSP3α, PvMSP3β) Genes and Eight Microsatellite Markers.The Korean journal of parasitology · 2019Article
- Genetic diversity of the Plasmodium vivax multidrug resistance 1 gene in Thai parasite populations.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018Article
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5 authors.
Funding
Abstract
backgroundPlasmodium vivax transmission in Thailand has been substantially reduced over the past 10 years, yet it remains highly endemic along international borders. Understanding the genetic relationship of residual parasite populations can help track the origins of the parasites that are reintroduced into malaria-free regions within the country. METHODOLOGY/
resultsA total of 127 P. vivax isolates were genotyped from two western provinces (Tak and Kanchanaburi) and one eastern province (Ubon Ratchathani) of Thailand using 10 microsatellite markers. Genetic diversity was high, but recent clonal expansion was detected in all three provinces. Substantial population structure and genetic differentiation of parasites among provinces suggest limited gene flow among these sites. There was no haplotype sharing among the three sites, and a reduced panel of four microsatellite markers was sufficient to assign the parasites to their provincial origins. CONCLUSION/SIGNIFICANCE: Significant parasite genetic differentiation between provinces shows successful interruption of parasite spread within Thailand, but high diversity along international borders implies a substantial parasite population size in these regions. The provincial origin of P. vivax cases can be reliably determined by genotyping four microsatellite markers, which should be useful for monitoring parasite reintroduction after malaria elimination.
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