Evidence map›Paper›PMID 29036016›Full record

Trial reportMedicine and science in sports and exercise2018

Exercise Preserves Physical Function in Prostate Cancer Patients with Bone Metastases.

Daniel A Galvão, Dennis R Taaffe, Nigel Spry, Prue Cormie, David Joseph, Suzanne K Chambers, Raphael Chee, Carolyn J Peddle-McIntyre, Nicolas H Hart, Freerk T Baumann and 3 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Medicine and science in sports and exercise, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04757064 (Efficacy of Selected Exercise Program on Distal End Femoral Sarcoma Patients Undergoing Knee Modular Endoprosthesis), which is not on this map. Cited by 104 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 16 pooled it
14.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04757064 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Efficacy of Selected Exercise Program on Distal End Femoral Sarcoma Patients Undergoing Knee Modular Endoprosthesis: RCT

TypeinterventionalSponsorCairo UniversityRan2021 to 2022Enrolled40ConditionsOsteosarcomaArmsstandard rehabilitation protocol
3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 16 syntheses or guidelines pooled it, 227 citations in OpenAlex.

  1. Pooled it
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  3. Effect of exercise on bone-related outcomes in patients with cancer affected by bone metastases or bone loss: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Pooled it
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  5. Non-pharmacological interventions targeting mobility among people with advanced cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  6. The role of exercise for pain management in adults living with and beyond cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  7. Pooled it
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  11. Do Patients with Prostate Cancer Benefit from Exercise Interventions? A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
    Pooled it
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  14. Pooled it
  15. Guideline
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  17. Trial
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44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 4 countries.

Daniel A GalvãoExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, AUSTRALIA.
Dennis R TaaffeExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, AUSTRALIA.
Nigel SpryExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, AUSTRALIA.
Prue CormieExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, AUSTRALIA.
David JosephExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, AUSTRALIA.
Suzanne K ChambersExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, AUSTRALIA.
Raphael CheeExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, AUSTRALIA.
Carolyn J Peddle-McIntyreExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, AUSTRALIA.
Nicolas H HartExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, AUSTRALIA.
Freerk T BaumannExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, AUSTRALIA.
James DenhamExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, AUSTRALIA.
Michael BakerExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, AUSTRALIA.
Robert U NewtonExercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, AUSTRALIA.
CancerCare · USUniversity of Newcastle Australia · AUUniversity of Queensland · AUAustralian Catholic University · AUCancer Council Queensland · AUGenesis HealthCare · USIntegrated Oncology (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe presence of bone metastases has excluded participation of cancer patients in exercise interventions and is a relative contraindication to supervised exercise in the community setting because of concerns of fragility fracture. We examined the efficacy and safety of a modular multimodal exercise program in prostate cancer patients with bone metastases.

methodsBetween 2012 and 2015, 57 prostate cancer patients (70.0 ± 8.4 yr; body mass index, 28.7 ± 4.0 kg·m) with bone metastases (pelvis, 75.4%; femur, 40.4%; rib/thoracic spine, 66.7%; lumbar spine, 43.9%; humerus, 24.6%; other sites, 70.2%) were randomized to multimodal supervised aerobic, resistance, and flexibility exercises undertaken thrice weekly (EX; n = 28) or usual care (CON; n = 29) for 3 months. Physical function subscale of the Medical Outcomes Study Short-Form 36 was the primary end point as an indicator of patient-rated physical functioning. Secondary end points included objective measures of physical function, lower body muscle strength, body composition, and fatigue. Safety was assessed by recording the incidence and severity of any adverse events, skeletal complications, and bone pain throughout the intervention.

resultsThere was a significant difference between groups for self-reported physical functioning (3.2 points; 95% confidence interval, 0.4-6.0 points; P = 0.028) and lower body muscle strength (6.6 kg; 95% confidence interval, 0.6-12.7; P = 0.033) at 3 months favoring EX. However, there was no difference between groups for lean mass (P = 0.584), fat mass (P = 0.598), or fatigue (P = 0.964). There were no exercise-related adverse events or skeletal fractures and no differences in bone pain between EX and CON (P = 0.507).

conclusionsMultimodal modular exercise in prostate cancer patients with bone metastases led to self-reported improvements in physical function and objectively measured lower body muscle strength with no skeletal complications or increased bone pain.

trial registrationACTRN12611001158954.

Indexed as

Exercise TherapyAgedBody CompositionBone NeoplasmsFatigueHumansMaleMiddle AgedMuscle StrengthProstatic Neoplasms

Identifiers

PMID29036016
PMCPMC5828380
OpenAlexW2761463273

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.