ArticleJournal of innate immunity2018
Nitric Oxide Mediates Insect Cellular Immunity via Phospholipase A2 Activation.
Article in Journal of innate immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- Cytotoxic and Immunological Effects of Terpinolene and 1-butyl-3,4-methylenedioxybenzene on Aedes aegypti Larvae.Archives of insect biochemistry and physiology · 2026Article
- Comparative Insights Into Detoxification, Regulation, and Evolution of Neonicotinoid Resistance in Three Planthoppers.Archives of insect biochemistry and physiology · 2026Review
- Interplay ofVirulence · 2025Article
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- In Silico Characterisation of theInternational journal of molecular sciences · 2023Article
- Exploring the Mystery of the Tetrahydrobiopterin Synthetic Defect Lethal MutantInternational journal of molecular sciences · 2022Article
- Immune Function of Endothelial Cells: Evolutionary Aspects, Molecular Biology and Role in Atherogenesis.International journal of molecular sciences · 2022Review
- Transcriptome analysis of the response to low temperature acclimation in Calliptamus italicus eggs.BMC genomics · 2022Article
- Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria.Nature chemistry · 2022Article
- Involvement of Fatty Acids and Their Metabolites in the Development of Inflammation in Atherosclerosis.International journal of molecular sciences · 2022Review
- Haemocyte-mediated immunity in insects: Cells, processes and associated components in the fight against pathogens and parasites.Immunology · 2021Review
- Chronic ciprofloxacin and atrazine co-exposure aggravates locomotor and exploratory deficits in non-target detritivore speckled cockroach (Nauphoeta cinerea).Environmental science and pollution research international · 2021Article
- Chikungunya virus entry is strongly inhibited by phospholipase A2 isolated from the venom of Crotalus durissus terrificus.Scientific reports · 2021Article
- Exposure to low doses of pesticides induces an immune response and the production of nitric oxide in honeybees.Scientific reports · 2021Article
- Nitric Oxide Synthase Regulates Gut Microbiota Homeostasis by ERK-NF-κB Pathway in Shrimp.Frontiers in immunology · 2021Article
- Entomotoxicity of jaburetox: revisiting the neurotoxic mechanisms in insects.Journal of venom research · 2020Review
- Prostaglandins and Other Eicosanoids in Insects: Biosynthesis and Biological Actions.Frontiers in physiology · 2018Review
- An Insect Prostaglandin EFrontiers in physiology · 2018Article
- Nitric oxide mediates antimicrobial peptide gene expression by activating eicosanoid signaling.PloS one · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After infection or invasion is recognized, biochemical mediators act in signaling insect immune functions. These include biogenic amines, insect cytokines, eicosanoids, and nitric oxide (NO). Treating insects or isolated hemocyte populations with different mediators often leads to similar results. Separate treatments with an insect cytokine, 2 biogenic amines, and an eicosanoid lead to a single result, hemocyte spreading, understood in terms of intracellular cross-talk among these signaling systems. This study focuses on the cross-talk between NO and eicosanoid signaling in our model insect, Spodoptera exigua. Bacterial injection increased NO concentrations in the larval hemocytes and fat body, and RNA interference (RNAi) of the S. exigua NO synthase (NOS) gene suppressed NO concentrations. RNAi treatment also led to a significant reduction in hemocyte nodulation following bacterial injection. Similar RNAi treatments led to significantly reduced PLA2 activities in the hemocytes and fat body compared to control larvae. Injection of L-NAME also prevented the induction of PLA2 activity following bacterial challenge. An injected NO donor, S-nitroso-N-acetyl-DL-penicillamine, increased PLA2 activity in a dose-dependent manner. However, eicosanoids did not influence NO concentrations in immune-challenged larvae. We infer that NO and eicosanoid signaling operate via cross-talk mechanisms in which the elevated NO concentrations activate PLA2 and eicosanoid biosynthesis, which finally mediates various immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.