Evidence map›Paper›PMID 29035695›Full record

ArticleApplied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme2018

Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.

Dongmei Liu, Flor Elisa Morales, Heidi B IglayReger, Mary K Treutelaar, Amy E Rothberg, Monica J Hubal, Evan P Nadler, Jacques Robidoux, Hisham Barakat, Jeffrey F Horowitz and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Dongmei Liua Department of Physical Medicine & Rehabilitation, University of Michigan, Ann Arbor, MI 48108, USA.
Flor Elisa Moralesc Department of Health, Human Performance and Recreation, Baylor University, Waco, TX 76798, USA.
Heidi B IglayRegera Department of Physical Medicine & Rehabilitation, University of Michigan, Ann Arbor, MI 48108, USA.
Mary K Treutelaard Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA.
Amy E Rothbergd Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA.
Monica J Hubale Children's National Medical Center, Washington, DC 20010, USA.
Evan P Nadlere Children's National Medical Center, Washington, DC 20010, USA.
Jacques Robidouxf Department of Pharmacology and Toxicology, East Carolina University, Greenville, NC 27858, USA.
Hisham Barakatf Department of Pharmacology and Toxicology, East Carolina University, Greenville, NC 27858, USA.
Jeffrey F Horowitzg School of Kinesiology, University of Michigan, Ann Arbor, MI 48109, USA.
Eric P Hoffmane Children's National Medical Center, Washington, DC 20010, USA.
Charles F Burantd Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA.
Paul M Gordona Department of Physical Medicine & Rehabilitation, University of Michigan, Ann Arbor, MI 48108, USA.
University of Michigan–Ann Arbor · USChildren's National · USBaylor University · USEast Carolina University · US

Funding

Pilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kanakadurga Singer · 2010 to 2026
$20.3M
Insulin sensitivity and fatty acid partitioning in skeletal muscle after exerciseR01DK077966 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOROWITZ, JEFFREY F · 2010 to 2020
$4.9M
NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK077966
6 · The paper itself

Abstract

Local inflammation in obese adipose tissue has been shown to contribute to insulin resistance; however, the role of macrophage infiltration within skeletal muscle is still debatable. This study aimed to evaluate the association of skeletal muscle macrophage gene expression with adiposity levels and insulin sensitivity in obese patients. Twenty-two nondiabetic obese patients and 23 healthy lean controls were included. Obese patients underwent a 3-month weight loss intervention. Macrophage gene expression in skeletal muscle (quantitative real-time polymerase chain reaction), body composition (dual-energy X-ray absorptiometry), and insulin sensitivity (homeostatic model assessment (HOMA) and oral glucose tolerance test) were compared between groups and their associations were analyzed. To validate skeletal muscle findings, we repeated the analyses with macrophage gene expression in adipose tissue. Expression levels of macrophage genes (CD68, CD11b, CD206, CD16, CD40, and CD163) were lower in skeletal muscle tissue of obese versus lean participants. Macrophage gene expression was also found to be inversely associated with adiposity, fasting insulin, and HOMA (r = -0.4 ∼ -0.6, p < 0.05), as well as positively associated with insulin sensitivity (r = 0.4 ∼ 0.8, p < 0.05). On the other hand, adipose tissue macrophage gene expression showed higher levels in obese versus lean participants, presenting a positive association with adiposity levels. Macrophage gene expression, in both skeletal and adipose tissue samples, was only minimally affected by the weight loss intervention. In contrast with the established positive relationship between adiposity and macrophage gene expression, an unexpected inverse correlation between these 2 variables was observed in skeletal muscle tissue. Additionally, muscle macrophage gene expression was inversely correlated with insulin resistance.

Indexed as

AdiposityInsulin ResistanceAbsorptiometry, PhotonAdultAntigens, CDAntigens, Differentiation, MyelomonocyticBody CompositionCase-Control StudiesCD11b AntigenCD163 AntigenCD68 MoleculeFemaleGlucose Tolerance TestGPI-Linked ProteinsHealth BehaviorHealth EducationAntigens, CDAntigens, Differentiation, MyelomonocyticCD11b AntigenCD163 AntigenCD68 antigen, humanCD68 MoleculeFCGR3B protein, humanGPI-Linked ProteinsInsulinITGAM protein, humanReceptors, Cell SurfaceReceptors, IgGadipose tissueinflammationinsulin sensitivityM1/M2 macrophagemacrophage M1/M2muscle squelettiqueperte de poidssensibilité à l’insulineskeletal muscletissu adipeuxweight loss

Identifiers

PMID29035695
PMCPMC6284171
OpenAlexW2766512799

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.