Evidence map›Paper›PMID 29035370›Full record

ArticleNature medicine2017

Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys.

Nicolas Huot, Beatrice Jacquelin, Thalia Garcia-Tellez, Philippe Rascle, Mickaël J Ploquin, Yoann Madec, R Keith Reeves, Nathalie Derreudre-Bosquet, Michaela Müller-Trutwin

Open access · greenAbstract read
In one paragraph

Article in Nature medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 135 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. HIV controllers, lessons learnt from the lymphoid tissues.Current opinion in HIV and AIDS · 2026
    Review
  8. Review
  9. Article
  10. Resident CD49aScience advances · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review

47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Nicolas HuotUnit on HIV, Inflammation and Persistence, Institut Pasteur, Paris, France.
Beatrice JacquelinUnit on HIV, Inflammation and Persistence, Institut Pasteur, Paris, France.
Thalia Garcia-TellezUnit on HIV, Inflammation and Persistence, Institut Pasteur, Paris, France.
Philippe RascleUnit on HIV, Inflammation and Persistence, Institut Pasteur, Paris, France.
Mickaël J PloquinUnit on HIV, Inflammation and Persistence, Institut Pasteur, Paris, France.
Yoann MadecEpidemiology Unit, Institut Pasteur, Paris, France.
R Keith ReevesCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Nathalie Derreudre-BosquetCommissariat à l'Energie Atomique et aux Énergies Alternatives (CEA), Université Paris Sud 11, INSERM U1184, Immunology of Viral Infections and Autoimmune Diseases (IMVA), Institut de Biologie François Jacob (IBJF), Infectious Disease Models and Innovative Therapies (IDMIT) Department, Fontenay-aux-Roses, France.
Michaela Müller-TrutwinUnit on HIV, Inflammation and Persistence, Institut Pasteur, Paris, France.
Institut Pasteur · FRBeth Israel Deaconess Medical Center · USCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FR

Funding

Nonhuman Primate Reagent ResourceU24AI126683 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Diogo Magnani · 2016 to 2026
$20.1M
Resource for Nonhuman Primate Cell Depleting AntibodiesR24OD010976 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ENGELMAN, KATHLEEN, MAGNANI, DIOGO · 2012 to 2019
$4.7M
Mechanisms of innate modulation of SIV reservoirs and opportunistic disease in the oral cavityR01DE026014 · NIDCR · BETH ISRAEL DEACONESS MEDICAL CENTER · PI REEVES, ROGER KEITH · 2016 to 2020
$3.4M
NIAID NIH HHS U24 AI126683NIDCR NIH HHS R01 DE026014NIH HHS R24 OD010976
6 · The paper itself

Abstract

Natural killer (NK) cells play an essential role in antiviral immunity, but knowledge of their function in secondary lymphoid organs is incomplete. Lymph node follicles constitute a major viral reservoir during infections with HIV-1 and simian immunodeficiency virus of macaques (SIVmac). In contrast, during nonpathogenic infection with SIV from African green monkeys (SIVagm), follicles remain generally virus free. We show that NK cells in secondary lymphoid organs from chronically SIVagm-infected African green monkeys (AGMs) were frequently CXCR5

Indexed as

AnimalsChlorocebus aethiopsDisease ReservoirsKiller Cells, NaturalLymph NodesSimian Immunodeficiency VirusVirus Replication

Identifiers

PMID29035370
PMCPMC6362838
OpenAlexW2767134981

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.